Morphologische Untersuchungen von Lymphknoten und Thymusin der Frühphase der SIV-Infektion bei Rhesus-Affen

Morpholoical alterations of lymph nodes and thymus during the early course of SIV infection of rhesus monkeys

Please always quote using this URN: urn:nbn:de:bvb:20-opus-47183
  • Rhesus monkeys (M. mulatta) were i. v. infected with SIV mac251. Three phases of lymph node changes were observed. 1: physiological follicular hyperplasia (3 and 6 weeks p.i.). 2: Alterations of germinal centers: loss of follicular mantle zone, fragmentation or sclerosis (12 and 24 weeks p.i.). 3: Partial depletion of T-lymphocytes, accumulation of plasma cells, increased numbers of syncytial giant cells, hemophgocytosis in the sinuses (about 1 year p.i.). The thymus of the juvenile animals showed first changes 12 and 24 weeks after infectionRhesus monkeys (M. mulatta) were i. v. infected with SIV mac251. Three phases of lymph node changes were observed. 1: physiological follicular hyperplasia (3 and 6 weeks p.i.). 2: Alterations of germinal centers: loss of follicular mantle zone, fragmentation or sclerosis (12 and 24 weeks p.i.). 3: Partial depletion of T-lymphocytes, accumulation of plasma cells, increased numbers of syncytial giant cells, hemophgocytosis in the sinuses (about 1 year p.i.). The thymus of the juvenile animals showed first changes 12 and 24 weeks after infection with focalloss of immature (and Ki-67 positive) cortical thymocytes, leading to severe accidental involution of the thymuses one year after infection and reduced numbers of Hassalls corpuscles. These investigations show the value of this animal model for the study of morphology and pathogenesis of AIDS.show moreshow less

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Metadaten
Author: J. G. Müller, Christiane Stahl-Hennig, Axel Rethwilm, C. Kneitz, Thomas Kerkau, B. Schmauser, C Schindler, V. Krenn, V. terMeulen, H.K. Müller-Hermelink
URN:urn:nbn:de:bvb:20-opus-47183
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Virologie und Immunbiologie
Language:German
Year of Completion:1991
Source:In: Verhandlungen der Deutschen Gesellschaft für Pathologie (1991) 75, 102-107
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Affenimmundefizienzvirus
Release Date:2010/08/17
Licence (German):License LogoDeutsches Urheberrecht