Structural and Functional Analysis of Chordin-like 2/BMP-2 Interaction
Please always quote using this URN: urn:nbn:de:bvb:20-opus-29120
- We have established the novel interaction between mCHL2, Tsg and BMP-2 for the first time. Tsg binds to VWC1 and VWC3 of mCHL2 in a cooperative waz and plazs a role in strengthening the binding affinity. Furthermore, Tsg/mCHL2/BMP-2 termary complex and Tsg/mCHL2 binary complex have been isolated by gel-filtration chromatography. Therefore mCHL2 can form a ternary complex with Tsg and BMP-2 and this complex makes mCHL2 a better BMP-2 antagnonist.
| Author: | Yi Huang |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-29120 |
| Document Type: | Doctoral Thesis |
| Granting Institution: | Universität Würzburg, Medizinische Fakultät |
| Faculties: | Medizinische Fakultät / Institut für Klinische Biochemie und Pathobiochemie |
| Date of final exam: | 2008/09/10 |
| Language: | English |
| Year of Completion: | 2008 |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Tag: | BMP-2 |
| Release Date: | 2008/10/08 |
| Advisor: | Prof. Walter Sebald |