The Manifold Roles of Sphingolipids in Viral Infections

Please always quote using this URN: urn:nbn:de:bvb:20-opus-246975
  • Sphingolipids are essential components of eukaryotic cells. In this review, we want to exemplarily illustrate what is known about the interactions of sphingolipids with various viruses at different steps of their replication cycles. This includes structural interactions during entry at the plasma membrane or endosomal membranes, early interactions leading to sphingolipid-mediated signal transduction, interactions with internal membranes and lipids during replication, and interactions during virus assembly and budding. Targeted interventions inSphingolipids are essential components of eukaryotic cells. In this review, we want to exemplarily illustrate what is known about the interactions of sphingolipids with various viruses at different steps of their replication cycles. This includes structural interactions during entry at the plasma membrane or endosomal membranes, early interactions leading to sphingolipid-mediated signal transduction, interactions with internal membranes and lipids during replication, and interactions during virus assembly and budding. Targeted interventions in sphingolipid metabolism – as far as they can be tolerated by cells and organisms – may open novel possibilities to support antiviral therapies. Human immunodeficiency virus type 1 (HIV-1) infections have intensively been studied, but for other viral infections, such as influenza A virus (IAV), measles virus (MV), hepatitis C virus (HCV), dengue virus, Ebola virus, and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), investigations are still in their beginnings. As many inhibitors of sphingolipid metabolism are already in clinical use against other diseases, repurposing studies for applications in some viral infections appear to be a promising approach.show moreshow less

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Metadaten
Author: Elita Avota, Jochen Bodem, Janice Chithelen, Putri Mandasari, Niklas Beyersdorf, Jürgen Schneider-Schaulies
URN:urn:nbn:de:bvb:20-opus-246975
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Virologie und Immunbiologie
Language:English
Parent Title (English):Frontiers in Physiology
ISSN:1664-042X
Year of Completion:2021
Volume:12
Article Number:715527
Source:Frontiers in Physiology (2021) 12:715527. doi: 10.3389/fphys.2021.715527
DOI:https://doi.org/10.3389/fphys.2021.715527
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:ceramide; plasma membrane; sphingolipid; sphingosine-1-phosphate; virus budding; virus entry; virus replication
Release Date:2022/02/11
Date of first Publication:2021/09/29
Open-Access-Publikationsfonds / Förderzeitraum 2021
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International