RNA structures and their role in selective genome packaging

Please always quote using this URN: urn:nbn:de:bvb:20-opus-246101
  • To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signals are constructed from local and long-range base pairings within viral genomes, as well as inter-molecular interactions between viral and host RNAs. Then, how genome packaging is regulated by the biophysical properties of RNA. Finally, we examineTo generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signals are constructed from local and long-range base pairings within viral genomes, as well as inter-molecular interactions between viral and host RNAs. Then, how genome packaging is regulated by the biophysical properties of RNA. Finally, we examine the impact of RNA packaging signals on viral evolution.show moreshow less

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Metadaten
Author: Liqing Ye, Uddhav B. Ambi, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Shazeb Ahmad, Patrick Bohn, Melanie M. Weber, Redmond P. Smyth
URN:urn:nbn:de:bvb:20-opus-246101
Document Type:Journal article
Faculties:Medizinische Fakultät
Language:English
Parent Title (English):Viruses
ISSN:1999-4915
Year of Completion:2021
Volume:13
Issue:9
Article Number:1788
Source:Viruses (2021) 13:9, 1788. https://doi.org/10.3390/v13091788
DOI:https://doi.org/10.3390/v13091788
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:RNA; RNA structure; RNA virus; evolution; genome packaging; viral assembly
Release Date:2022/11/23
Date of first Publication:2021/09/08
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International