Leptin improves parameters of brown adipose tissue thermogenesis in lipodystrophic mice

Please always quote using this URN: urn:nbn:de:bvb:20-opus-242787
  • Lipodystrophy syndromes (LD) are a heterogeneous group of very rare congenital or acquired disorders characterized by a generalized or partial lack of adipose tissue. They are strongly associated with severe metabolic dysfunction due to ectopic fat accumulation in the liver and other organs and the dysregulation of several key adipokines, including leptin. Treatment with leptin or its analogues is therefore sufficient to reverse some of the metabolic symptoms of LD in patients and in mouse models through distinct mechanisms. Brown adiposeLipodystrophy syndromes (LD) are a heterogeneous group of very rare congenital or acquired disorders characterized by a generalized or partial lack of adipose tissue. They are strongly associated with severe metabolic dysfunction due to ectopic fat accumulation in the liver and other organs and the dysregulation of several key adipokines, including leptin. Treatment with leptin or its analogues is therefore sufficient to reverse some of the metabolic symptoms of LD in patients and in mouse models through distinct mechanisms. Brown adipose tissue (BAT) thermogenesis has emerged as an important regulator of systemic metabolism in rodents and in humans, but it is poorly understood how leptin impacts BAT in LD. Here, we show in transgenic C57Bl/6 mice overexpressing sterol regulatory element-binding protein 1c in adipose tissue (Tg (aP2-nSREBP1c)), an established model of congenital LD, that daily subcutaneous administration of 3 mg/kg leptin for 6 to 8 weeks increases body temperature without affecting food intake or body weight. This is associated with increased protein expression of the thermogenic molecule uncoupling protein 1 (UCP1) and the sympathetic nerve marker tyrosine hydroxylase (TH) in BAT. These findings suggest that leptin treatment in LD stimulates BAT thermogenesis through sympathetic nerves, which might contribute to some of its metabolic benefits by providing a healthy reservoir for excess circulating nutrients.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: Annett Hoffmann, Thomas Ebert, Mohammed K. Hankir, Gesine Flehmig, Nora Klöting, Beate Jessnitzer, Ulrike Lössner, Michael Stumvoll, Matthias Blüher, Mathias Fasshauer, Anke Tönjes, Konstanze Miehle, Susan Kralisch
URN:urn:nbn:de:bvb:20-opus-242787
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I)
Language:English
Parent Title (English):Nutrients
ISSN:2072-6643
Year of Completion:2021
Volume:13
Issue:8
Article Number:2499
Source:Nutrients (2021) 13:8, 2499. https://doi.org/10.3390/nu13082499
DOI:https://doi.org/10.3390/nu13082499
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:brown adipose tissue; leptin; lipodystrophy; sympathetic nervous system; thermogenesis; uncoupling protein 1
Release Date:2022/08/03
Date of first Publication:2021/07/22
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International