Zhiqiang Liu, Yudha P. Budiman, Ya‐Ming Tian, Alexandra Friedrich, Mingming Huang, Stephen A. Westcott, Udo Radius, Todd B. Marder

• We report herein a mild procedure for the copper‐catalyzed oxidative cross‐coupling of electron‐deficient polyfluorophenylboronate esters with terminal alkynes. This method displays good functional group tolerance and broad substrate scope, generating cross‐coupled alkynyl(fluoro)arene products in moderate to excellent yields. Thus, it represents a simple alternative to the conventional Sonogashira reaction.