The oak−wood extract Robuvit\(^®\) improves recovery and oxidative stress after hysterectomy: a randomized, double-blind, placebo-controlled pilot study

Please always quote using this URN: urn:nbn:de:bvb:20-opus-203265
  • Hysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract from French oak wood (Quercus robur) containing at least 40% polyphenols of the ellagitannins class, Robuvit\(^®\), on convalescence and oxidative stress of women after hysterectomy. Recovery status was monitored with the SF-36 questionnaire. TheHysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract from French oak wood (Quercus robur) containing at least 40% polyphenols of the ellagitannins class, Robuvit\(^®\), on convalescence and oxidative stress of women after hysterectomy. Recovery status was monitored with the SF-36 questionnaire. The supplementation with Robuvit\(^®\) (300 mg/day) during 4 weeks significantly improved general and mental health, while under placebo some items significantly deteriorated. Oxidative stress and enhancement of MMP–9 activity was significantly reduced by Robuvit\(^®\) versus placebo. After 8 weeks of intervention, the patients’ condition improved independently of the intervention. Our results suggest that the use of Robuvit\(^®\) as a natural supplement relieves post-operative symptoms of patients after hysterectomy and reduces oxidative stress. The study was registered with ID ISRCTN 11457040 (13/09/2019).show moreshow less

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Metadaten
Author: Vladimír Ferianec, Matej Fülöp, Miriam Ježovičová, Jana Radošinská, Marta Husseinová, Michaela Feriancová, Dominika Radošinská, Miroslav Barančík, Jana Muchová, Petra Hȍgger, Zdeňka Ďuračková
URN:urn:nbn:de:bvb:20-opus-203265
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Institut für Pharmazie und Lebensmittelchemie
Language:English
Parent Title (English):Nutrients
ISSN:2072-6643
Year of Completion:2020
Volume:12
Issue:4
Article Number:913
Source:Nutrients (2020) 12:4, 913. https://doi.org/10.3390/nu12040913
DOI:https://doi.org/10.3390/nu12040913
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 615 Pharmakologie, Therapeutik
Tag:Robuvit\(^®\); complementary medicine; hysterectomy; matrix metalloproteinases; oak wood extract; oxidative stress; post-operative recovery
Release Date:2022/05/19
Date of first Publication:2020/03/27
EU-Project number / Contract (GA) number:26230120009
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International