Isolation of a Cancer-Associated Microchromosome in the Sperm-Dependent Parthenogen Poecilia formosa

Please always quote using this URN: urn:nbn:de:bvb:20-opus-196785
  • In the asexual all-female fish species Poecilia formosa, the Amazon molly, supernumerary chromosomes have frequently been found in both laboratory-reared and wild-caught individuals. While wild-caught individuals with B chromosomes are phenotypically indifferent from conspecifics, individuals carrying B chromosomes from recent introgression events in the laboratory show phenotypic changes. Former analyses showed that the expression of a pigment cell locus is associated with the presence of these B chromosomes. In addition, they contain a so farIn the asexual all-female fish species Poecilia formosa, the Amazon molly, supernumerary chromosomes have frequently been found in both laboratory-reared and wild-caught individuals. While wild-caught individuals with B chromosomes are phenotypically indifferent from conspecifics, individuals carrying B chromosomes from recent introgression events in the laboratory show phenotypic changes. Former analyses showed that the expression of a pigment cell locus is associated with the presence of these B chromosomes. In addition, they contain a so far unidentified locus that confers a higher susceptibility to tumor formation in the presence of pigmentation pattern. Isolation by microdissection and hybridization to metaphase chromosomes revealed that they contain one or several sequences with similarity to a highly repetitive pericentromeric and subtelomeric sequence in A chromosomes. Isolation of one particular sequence by AFLP showed that the B chromosomes contain at least 1 copy of an A-chromosomal region which is highly conserved in the whole genus Poecilia, i.e. more than 5 million years old. We propose it to be a single copy sequence.show moreshow less

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Metadaten
Author: D. K. Lamatsch, V. Trifonov, S. Schories, J. T. Epplen, M. Schmid, M. Schartl
URN:urn:nbn:de:bvb:20-opus-196785
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Humangenetik
Medizinische Fakultät / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Cytogenetic and Genome Research
ISSN:1424-8581
ISSN:1424-859X
Year of Completion:2011
Volume:135
Issue:2
Pagenumber:135-142
Source:Cytogenetic and Genome Research 2011;135(2):135–142. DOI: 10.1159/000331271
DOI:https://doi.org/10.1159/000331271
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/21952475
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:AFLP; B chromosomes; asexual reproduction; gynogenesis; microdissection; paternal introgression; telomeres
Release Date:2021/08/20
Date of first Publication:2011/09/21
Note:
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Licence (German):License LogoDeutsches Urheberrecht