High-risk human papillomavirus infection in Bowen’s disease of the nail unit: report of three cases and review of the literature

Please always quote using this URN: urn:nbn:de:bvb:20-opus-196638
  • Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. Results:Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected. Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.show moreshow less

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Metadaten
Author: Natalie Grundmeier, Henning Hamm, Benedikt Weissbrich, Sabrina Christine Lang, Eva-Bettina Bröcker, Andreas Kerstan
URN:urn:nbn:de:bvb:20-opus-196638
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Virologie und Immunbiologie
Medizinische Fakultät / Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Language:English
Parent Title (English):Dermatology
ISSN:1018-8665
ISSN:1421-9832
Year of Completion:2012
Volume:223
Issue:4
First Page:293
Last Page:300
Source:Dermatology (2012) 223:4, 293-300. https://doi.org/10.1159/000335371
DOI:https://doi.org/10.1159/000335371
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/22269697
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Bowen’s disease, periungual; Human papillomavirus; Nail unit
Release Date:2022/03/23
Date of first Publication:2012/01/24
Note:
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Licence (German):License LogoDeutsches Urheberrecht