Neuroinflammation in the peripheral nerve: cause, modulator, or bystander in peripheral neuropathies?

Please always quote using this URN: urn:nbn:de:bvb:20-opus-189696
  • The role of innate and adaptive inflammation as a primary driver or modifier of neuropathy in premorbidly normal nerves, and as a critical player in amplifying neuropathies of other known causes (e.g., genetic, metabolic) is incompletely understood and under-researched, despite unmet clinical need. Also, cellular and humoral components of the adaptive and innate immune system are substantial disease modifying agents in the context of neuropathies and, at least in some neuropathies, there is an identified tight interrelationship between bothThe role of innate and adaptive inflammation as a primary driver or modifier of neuropathy in premorbidly normal nerves, and as a critical player in amplifying neuropathies of other known causes (e.g., genetic, metabolic) is incompletely understood and under-researched, despite unmet clinical need. Also, cellular and humoral components of the adaptive and innate immune system are substantial disease modifying agents in the context of neuropathies and, at least in some neuropathies, there is an identified tight interrelationship between both compartments of the immune system. Additionally, the quadruple relationship between Schwann cell, axon, macrophage, and endoneurial fibroblast, with their diverse membrane bound and soluble signalling systems, forms a distinct focus for investigation in nerve diseases with inflammation secondary to Schwann cell mutations and possibly others. Identification of key immunological effector pathways that amplify neuropathic features and associated clinical symptomatology including pain should lead to realistic and timely possibilities for translatable therapeutic interventions using existing immunomodulators, alongside the development of novel therapeutic targets.show moreshow less

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Metadaten
Author: Rudolf Martini, Hugh Willison
URN:urn:nbn:de:bvb:20-opus-189696
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurologische Klinik und Poliklinik
Language:English
Parent Title (English):GLIA
Year of Completion:2016
Volume:64
Issue:4
Pagenumber:475-486
Source:GLIA (2016) 64:4, S. 475-486. https://doi.org/10.1002/glia.22899
DOI:https://doi.org/10.1002/glia.22899
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Charcot-Marie-Tooth; Guillain-Barré-Syndrom; Schwann cell dedifferentiation; adaptive immune system; familial amyloidotic polyneuropathy; fibroblast; glycation end products; innate immune system; lymphocytes; macrophage; motor axonal neuropathy; nodes of Ranvier
Release Date:2021/01/14
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International