Delineation of Chondroid Lipoma: An Immunohistochemical and Molecular Biological Analysis

Please always quote using this URN: urn:nbn:de:bvb:20-opus-135103
  • Aims Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation (11;16). Here, we analyze CL and its histological mimics. Methods CL ( ) was compared to a variety of histological mimics ( ) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. Results All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. InAims Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation (11;16). Here, we analyze CL and its histological mimics. Methods CL ( ) was compared to a variety of histological mimics ( ) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. Results All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas, CCND1 was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement of CCND1 and FUS as translocation partners. Conclusions Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.show moreshow less

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Metadaten
Author: Ronald S. A. de Vreeze, Frits van Coevorden, Lucie Boerrigter, Petra M. Nederlof, Rick L. Haas, Johannes Bras, Andreas Rosenwald, Thomas Mentzel, Daphne de Jong
URN:urn:nbn:de:bvb:20-opus-135103
Document Type:Journal article
Faculties:Medizinische Fakultät / Pathologisches Institut
Language:English
Parent Title (English):Sarcoma
Year of Completion:2011
Volume:2011
Issue:Article ID 638403
Pagenumber:5
Source:Sarcoma Volume 2011, Article ID 638403, 5 pages
DOI:https://doi.org/10.1155/2011/638403
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Tag:Lipom
Release Date:2019/03/26
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung