Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells

Please always quote using this URN: urn:nbn:de:bvb:20-opus-131851
  • Pentacyclic triterpenes are a large family of plant metabolites that exhibit a wide array of biological activities. The genus Cecropia, which encompasses many plant species, has been used as traditional medicine for the treatment of inflammatory diseases and is known to produce many active pentacyclic triterpenes. In this study we investigated the chemical composition of a pentacyclic triterpene fraction from the roots of Cecropia telenitida Cuatrec., Urticaceae. A novel compound, which we termed yarumic acid, and four known molecules (serjanicPentacyclic triterpenes are a large family of plant metabolites that exhibit a wide array of biological activities. The genus Cecropia, which encompasses many plant species, has been used as traditional medicine for the treatment of inflammatory diseases and is known to produce many active pentacyclic triterpenes. In this study we investigated the chemical composition of a pentacyclic triterpene fraction from the roots of Cecropia telenitida Cuatrec., Urticaceae. A novel compound, which we termed yarumic acid, and four known molecules (serjanic acid, spergulagenic acid A, 20-hydroxy-ursolic acid and goreishic acid I) were isolated and characterised. In a dendritic cell (DC)-based assay, we demonstrated that non-toxic doses of these pentacyclic triterpenes inhibited the secretion of at least one of the proinflammatory cytokines tested (IL-1 beta, IL-12p40, IL-12p70, TNF-alpha). Spergulagenic acid A also inhibited nitric oxide production in lipopolysaccharide-stimulated dendritic cell. Serjanic acid and spergulagenic acid A, which were the most potent abundant compounds in the pentacyclic triterpene fraction, showed the most activity in the dendritic cell-based assay. These results show that all pentacyclic triterpenes might contribute to the anti-inflammatory activities of C. telenitida. Moreover, yarumic acid as well as the four known pentacyclic triterpenes, can be exploited as potential immunomodulatory/anti-inflammatory agents.show moreshow less

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Metadaten
Author: Guillermo L. Montoya Peláez, Jelver A. Sierra, Fernando Alzate, Ulrike Holzgrabe, José R. Ramirez-Pineda
URN:urn:nbn:de:bvb:20-opus-131851
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Institut für Pharmazie und Lebensmittelchemie
Language:English
Parent Title (English):Revista Brasileira de Farmacognosia - Brazilian Journal of Pharmacognosy
Year of Completion:2013
Volume:23
Pagenumber:754-761
Source:Revista Brasileira de Farmacognosia 23(2013): 754-761
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 615 Pharmakologie, Therapeutik
Tag:anti-inflammatory activity; bone marrow; cecropia telenitida; chenopodium quinoa; cytokine modulation; cytokine production; dendritic cells; kappa-B activation; macrophages; natural product; nitric oxide; obtusifolia bertol; oleanane saponins; pentacyclic triterpene; psidium guajava;; ursolic acid
Release Date:2016/05/23
Licence (German):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitung