Nature's Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain

Please always quote using this URN: urn:nbn:de:bvb:20-opus-116816
  • Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against theEight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.show moreshow less

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Metadaten
Author: Anna Lena Kunz, Antje Labes, Jutta Wiese, Torsten Bruhn, Gerhard Bringmann, Johannes F. Imhoff
URN:urn:nbn:de:bvb:20-opus-116816
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Institut für Organische Chemie
Language:English
Parent Title (English):Marine Drugs
ISSN:1660-3397
Year of Completion:2014
Volume:12
Issue:4
Pagenumber:1699-1714
Source:Marine Drugs 2014, 12, 1699-1714; doi:10.3390/md12041699
DOI:https://doi.org/10.3390/md12041699
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/24670532
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Tag:Baltic Sea; absolute configuration; biosynthesis; halichondria panicea; marine natural product; obstructive pulmonary disease; phenazine; phosphodiesterase-4 inhibitor; rofumilast; streptomyces
Release Date:2015/08/12
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung