ORCID: https://orcid.org/0000-0002-2792-9595; Becker, Sidney ORCID: https://orcid.org/0000-0002-4746-2822; Tiede, Niklas; Wiedemann, Stefan; Feldmann, Jonas ORCID: https://orcid.org/0000-0002-3887-2213 und Carell, Thomas ORCID: https://orcid.org/0000-0001-7898-2831
(7. Januar 2019):
A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions.
In: Chemical Communications, Bd. 55: S. 1939-1942
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Abstract
Herein, we report a new prebiotically plausible pathway towards a pyrimidine nucleobase in continuous manner. The route involves simultaneous methylation and carbamoylation of cyanoacetylene-derived alpha,beta-unsaturated thioamide with N-methyl-N-nitrosourea (MNU) in aqueous media. This provides S-methylpyrimidinone in one-pot, which can be converted into a variety of 4-substituted pyrimidine nucleobases including cytosine and uracil.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| EU Funded Grant Agreement Number: | 741912 |
| EU-Projekte: | Horizon 2020 > ERC Grants > ERC Advanced Grant > ERC Grant 741912: EPiR - The Chemical Basis of RNA Epigenetics
Horizon 2020 > Marie Skłodowska Curie Actions > Marie Skłodowska-Curie Individual Fellowships > 752420: PRENUCRNA - Prebiotic Synthesis of Pyrimidine Nucleosides: New Insights into RNA Evolution |
| Publikationsform: | Postprint |
| Fakultät: | Chemie und Pharmazie > Department Chemie |
| Fakultätsübergreifende Einrichtungen: | Center for Integrated Protein Science Munich (CIPSM) |
| Themengebiete: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| URN: | urn:nbn:de:bvb:19-epub-61634-5 |
| ISSN: | 1359-7345 |
| Sprache: | Englisch |
| Dokumenten ID: | 61634 |
| Datum der Veröffentlichung auf Open Access LMU: | 09. Apr. 2019, 13:24 |
| Letzte Änderungen: | 04. Nov. 2020, 13:39 |
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