- AutorIn
- Azaam Aziz Leibniz Institute for Solid State and Materials Research, Dresden
- Richard NauberLeibniz Institute for Solid State and Materials Research, Dresden
- Ana Sánchez IglesiasBiomedical Research Networking Center for Bioengineering, Biomaterials and Nanomedicine, Donostia-San Sebastián, Spain
- Min Tang
- Libo Ma
- Luis M. Liz-Marzán
- Oliver G. Schmidt
- Mariana Medina-Sánchez
- Titel
- Nanomaterial-decorated micromotors for enhanced photoacoustic imaging
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:ch1-qucosa2-879560
- Quellenangabe
- Journal of Micro-Bio Robotics Jahrgang: 2023
ISSN: 2194-6418
E-ISSN: 2194-6426 - Erstveröffentlichung
- 2023
- Abstract (EN)
- Micro-and nanorobots have the potential to perform non-invasive drug delivery, sensing, and surgery in living organisms, with the aid of diverse medical imaging techniques. To perform such actions, microrobots require high spatiotemporal resolution tracking with real-time closed-loop feedback. To that end, photoacoustic imaging has appeared as a promising technique for imaging microrobots in deep tissue with higher molecular specificity and contrast. Here, we present different strategies to track magnetically-driven micromotors with improved contrast and specificity using dedicated contrast agents (Au nanorods and nanostars). Furthermore, we discuss the possibility of improving the light absorption properties of the employed nanomaterials considering possible light scattering and coupling to the underlying metal-oxide layers on the micromotor’s surface. For that, 2D COMSOL simulation and experimental results were correlated, confirming that an increased spacing between the Au-nanostructures and the increase of thickness of the underlying oxide layer lead to enhanced light absorption and preservation of the characteristic absorption peak. These characteristics are important when visualizing the micromotors in a complex in vivo environment, to distinguish them from the light absorption properties of the surrounding natural chromophores.
- Andere Ausgabe
- DOI: 10.1007/s12213-023-00156-7
- Freie Schlagwörter (EN)
- Photoacoustics, Micromotors, Closed-loop control, Gold nanorods/stars, Medical imaging
- Klassifikation (DDC)
- 621.3
- Normschlagwörter (GND)
- Nanoelektronik, Kleinstmotor, Bildgebendes Verfahren
- Herausgeber (Institution)
- Technische Universität Chemnitz
- Verlag
- Springer Nature, Berlin
- Förder- / Projektangaben
- European Research Council (ERC)
ID: 835268 ; 853609 ; 787510 - Spanish State Research Agency ID: MDM- 2017-0720
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:ch1-qucosa2-879560
- Veröffentlichungsdatum Qucosa
- 13.11.2023
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
- CC BY 4.0