Debunking mathematically the logical fallacy that cancer risk is just “bad luck”

Sornette, Didier; Favre, Maroussia

Debunking mathematically the logical fallacy that cancer risk is just “bad luck”

Dateien

Sornette_2-vy44p9wo62r61.pdfGröße: 403.97 KBDownloads: 171

Datum

2015

Autor:innen

Sornette, Didier

Favre, Maroussia

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Informatik und Informationswissenschaft

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Zusammenfassung

Tomasetti and Vogelstein recently proposed that the majority of variation in cancer risk among tissues is due to “bad luck,” that is, random mutations arising during DNA replication in normal noncancerous stem cells. They generalize this finding to cancer overall, claiming that “the stochastic effects of DNA replication appear to be the major contributor to cancer in humans.” We show that this conclusion results from a logical fallacy based on ignoring the influence of population heterogeneity in correlations exhibited at the level of the whole population. Because environmental and genetic factors cannot explain the huge differences in cancer rates between different organs, it is wrong to conclude that these factors play a minor role in cancer rates. In contrast, we show that one can indeed measure huge differences in cancer rates between different organs and, at the same time, observe a strong effect of environmental and genetic factors in cancer rates.

Fachgebiet (DDC)

004 Informatik

Schlagwörter

Cancer Risk, Familial Adenomatous Polyposis, Lung Cancer Risk, Cancer Rate, Huge Difference

Zitieren

ISO 690

SORNETTE, Didier, Maroussia FAVRE, 2015. Debunking mathematically the logical fallacy that cancer risk is just “bad luck”. In: EPJ Nonlinear Biomedical Physics. 2015, 3, 10. eISSN 2195-0008. Available under: doi: 10.1140/epjnbp/s40366-015-0026-0

BibTex

@article{Sornette2015Debun-44706,
  year={2015},
  doi={10.1140/epjnbp/s40366-015-0026-0},
  title={Debunking mathematically the logical fallacy that cancer risk is just “bad luck”},
  volume={3},
  journal={EPJ Nonlinear Biomedical Physics},
  author={Sornette, Didier and Favre, Maroussia},
  note={Article Number: 10}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/44706">
    <dc:language>eng</dc:language>
    <dc:contributor>Favre, Maroussia</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dc:creator>Favre, Maroussia</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/44706/3/Sornette_2-vy44p9wo62r61.pdf"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
    <dc:contributor>Sornette, Didier</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-01-23T17:18:34Z</dc:date>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-01-23T17:18:34Z</dcterms:available>
    <dcterms:issued>2015</dcterms:issued>
    <dcterms:abstract xml:lang="eng">Tomasetti and Vogelstein recently proposed that the majority of variation in cancer risk among tissues is due to “bad luck,” that is, random mutations arising during DNA replication in normal noncancerous stem cells. They generalize this finding to cancer overall, claiming that “the stochastic effects of DNA replication appear to be the major contributor to cancer in humans.” We show that this conclusion results from a logical fallacy based on ignoring the influence of population heterogeneity in correlations exhibited at the level of the whole population. Because environmental and genetic factors cannot explain the huge differences in cancer rates between different organs, it is wrong to conclude that these factors play a minor role in cancer rates. In contrast, we show that one can indeed measure huge differences in cancer rates between different organs and, at the same time, observe a strong effect of environmental and genetic factors in cancer rates.</dcterms:abstract>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/44706"/>
    <dc:creator>Sornette, Didier</dc:creator>
    <dcterms:title>Debunking mathematically the logical fallacy that cancer risk is just “bad luck”</dcterms:title>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/44706/3/Sornette_2-vy44p9wo62r61.pdf"/>
  </rdf:Description>
</rdf:RDF>

Universitätsbibliographie

Nein