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doi:10.22028/D291-36377
Titel: | Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk |
VerfasserIn: | Böhm, Michael Schumacher, Helmut Werner, Christian Teo, Koon K. Lonn, Eva M. Mahfoud, Felix Speer, Thimoteus Mancia, Giuseppe Redon, Josep Schmieder, Roland E. Sliwa, Karen Marx, Nikolaus Weber, Michael A. Laufs, Ulrich Williams, Bryan Yusuf, Salim Mann, Johannes F. E. |
Sprache: | Englisch |
Titel: | Cardiovascular Diabetology |
Bandnummer: | 21 |
Heft: | 1 |
Verlag/Plattform: | BMC |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | Physical activity Cardiovascular outcomes Renal outcomes Secondary prevention |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background: Guidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged≥55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program. Methods: Analyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and χ2 - test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed. Results: Physical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p<0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p=0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p=0.05). Conclusions: Moderate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully difer with or without diabetes but absolute beneft of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity. Clinical trial registration: http://clinicaltrials.gov.uniqueidentifer:NCT00153101. |
DOI der Erstveröffentlichung: | 10.1186/s12933-021-01429-w |
URL der Erstveröffentlichung: | https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01429-w |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-363774 hdl:20.500.11880/33029 http://dx.doi.org/10.22028/D291-36377 |
ISSN: | 1475-2840 |
Datum des Eintrags: | 7-Jun-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Information |
In Beziehung stehendes Objekt: | https://ndownloader.figstatic.com/files/33649199 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Michael Böhm M - Dr. med. Dr. sc.nat. Timo Speer |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s12933-021-01429-w.pdf | 1,21 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons