- AutorIn
- Chrysanthi Tsamadou
- Daphne Engelhardt
- Uwe Platzbecker
- Elisa Sala
- Thomas Valerius
- Eva Wagner-Drouet
- Gerald Wulf
- Nicolaus Kröger
- Niels Murawski
- Herrmann Einsele
- Kerstin Schaefer-Eckart
- Sebastian Freitag
- Jochen Caspar
- Martin Kaufmann
- Mareike Dürholt
- Bernd Herstenstein
- Stefan Klein
- Mark Ringhoffer
- Sandra Frank
- Christine Neuchel
- Titel
- HLA-DRB3/4/5 Matching Improves Outcome of Unrelated Hematopoietic Stem Cell Transplantation
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-843086
- Quellenangabe
- Frontiers in immunology
Erscheinungsjahr: 2021
Jahrgang: 12
ISSN: 1664-3224
Artikelnummer: 771449 - Erstveröffentlichung
- 2021
- Abstract (EN)
- The HLA-DRB3/4/5 loci are closely linked to the HLA-DRB1 gene. Mismatches in these loci occur with a frequency of about 8%–12% in otherwise 10/10 HLA-matched transplant pairs. There is preliminary evidence that these disparities may associate with increased acute graft-versus-host disease (GvHD) rates. The aim of this study was to analyze a large cohort of German patients and their donors for HLA-DRB3/4/5 compatibility and to correlate the HLA-DRB3/4/5 matching status with the outcome of unrelated hematopoietic stem cell transplantation (uHSCT). To this end, 3,410 patients and their respective donors were HLA-DRB3/4/5 and HLA-DPB1 typed by amplicon-based nextgeneration sequencing (NGS). All patients included received their first allogeneic transplant for malignant hematologic diseases between 2000 and 2014. Mismatches in the antigen recognition domain (ARD) of HLA-DRB3/4/5 genes were correlated with clinical outcome. HLA-DRB3/4/5 incompatibility was seen in 12.5% (n = 296) and 17.8% (n = 185) of the 10/10 and 9/10 HLA-matched cases, respectively. HLA-DRB3/4/5 mismatches in the ARD associated with a worse overall survival (OS), as shown in univariate (5-year OS: 46.1% vs. 39.8%, log-rank p = 0.038) and multivariate analyses [hazard ratio (HR) 1.25, 95% CI 1.02–1.54, p = 0.034] in the otherwise 10/10 HLAmatched subgroup. The worse outcome was mainly driven by a significantly higher nonrelapse mortality (HR 1.35, 95% CI 1.05–1.73, p = 0.017). In the 9/10 HLA-matched cases, the effect was not statistically significant. Our study results suggest that mismatches within the ARD of HLA-DRB3/4/5 genes significantly impact the outcome of otherwise fully matched uHSCT and support their consideration upon donor selection in the future.
- Andere Ausgabe
- Link zur Erstveröffentlichung
Link: https://doi.org/10.3389/fimmu.2021.771449 - Freie Schlagwörter (EN)
- HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRB3/4/5, unrelated hematopoietic stem cell transplantation (uHSCT), HLA-matched, DRB3/4/5 matching
- Klassifikation (DDC)
- 610
- Verlag
- Frontiers Research Foundation, Lausanne
- Förder- / Projektangaben
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-843086
- Veröffentlichungsdatum Qucosa
- 24.03.2023
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
- CC BY 4.0