- AutorIn
- David Ulbricht
- Catherine A. Tindall
- Kathrin Oertwig
- Stefanie Hanke
- Norbert Sträter
- John T. Heiker
- Titel
- Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-380218
- Quellenangabe
- Biological Chemistry Erscheinungsort: Berlin
Verlag: de Gruyter
Erscheinungsjahr: 2018
Jahrgang: 399
Heft: 9
Seiten: 1079-1084
E-ISSN: 1437-4315 - Erstveröffentlichung
- 2018
- DOI
- https://doi.org/https://doi.org/10.1515/hsz-2018-0108
- Abstract (EN)
- Kallikrein-related peptidases KLK5, KLK7 and KLK14 are important proteases in skin desquamation and aberrant KLK activity is associated with inflammatory skin diseases such as Netherton syndrome but also with various serious forms of cancer. Previously, we have identified KLK7 as the first protease target of vaspin (Serpin A12). Here, we report KLK14 as a second KLK protease to be inhibited by vaspin. In conclusion, vaspin represents a multispecific serpin targeting the kallikrein proteases KLK7 and KLK14, with distinct exosites regulating recognition of these target proteases and opposing effects of heparin binding on the inhibition reaction.
- Andere Ausgabe
- Link zur Originalpublikation
Link: https://www.degruyter.com/view/j/bchm.2018.399.issue-9/hsz-2018-0108/hsz-2018-0108.xml
DOI: 10.1515/hsz-2018-0108 - Freie Schlagwörter (EN)
- Adipokine, Exosite, Kallikrein, Obesity, Diabetes, Metabolic syndrome, Inflammation, Serine protease, Serpin A12, Site‐directed mutagenesis, Structural biology
- Klassifikation (DDC)
- 572
- Version / Begutachtungsstatus
- angenommene Version / Postprint / Autorenversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-380218
- Veröffentlichungsdatum Qucosa
- 27.01.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch