- AutorIn
- Andrea Tanzer
- Peter F. Stadler
- Titel
- Molecular Evolution of a MicroRNA Cluster
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-319110
- Quellenangabe
- Journal of Molecular Biology Verlag: Elsevier
Erscheinungsjahr: 2004
Jahrgang: 339
Heft: 2
Seiten: 327-335
ISSN: 0022-2836 - Erstveröffentlichung
- 2004
- Abstract (EN)
- Many of the known microRNAs are encoded in polycistronic transcripts. Here, we reconstruct the evolutionary history of the mir17 microRNA clusters which consist of miR-17, miR-18, miR-19a, miR-19b, miR-20, miR-25, miR-92, miR-93, miR-106a, and miR-106b. The history of this cluster is governed by an initial phase of local (tandem) duplications, a series of duplications of entire clusters and subsequent loss of individual microRNAs from the resulting paralogous clusters. The complex history of the mir17 microRNA family appears to be closely linked to the early evolution of the vertebrate lineage.
- Freie Schlagwörter (EN)
- Biochemistry, Molecular evolution, RNA
- Klassifikation (DDC)
- 572.8
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-319110
- Veröffentlichungsdatum Qucosa
- 16.10.2018
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch