- AutorIn
- Andreas Buchmann
- Titel
- Adjuvante systemische Azithromycingabe im Vergleich zu Amoxicillin/Metronidazol bei Scaling and root planing in einer privaten zahnärztlichen Praxis – eine prospektive randomisierte klinische Untersuchung
- Untertitel
- Adjuvante systemische Azithromycingabe im Vergleich zu Amoxicillin/Metronidazol bei Scaling and root planing in einer privaten zahnärztlichen Praxis – eine prospektive randomisierte klinische Untersuchung
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa-222327
- Datum der Einreichung
- 14.07.2016
- Datum der Verteidigung
- 01.03.2017
- Abstract (EN)
- Abstract OBJECTIVES: The objective of the present study is to compare the effect of systemic adjunctive use of azithromycin with amoxicillin/metronidazole to scaling and root planing (SRP) in a clinical study. MATERIALS AND METHODS: Data from 60 individuals with chronic periodontitis were evaluated after full-mouth SRP. Antibiotics were given from the first day of SRP, in the test group (n = 29), azithromycin for 3 days and, in the control group (n = 31), amoxicillin/metronidazole for7 days. Probing depth (PD), attachment level (AL), and bleeding on probing (BOP) were recorded at baseline and after 3 and 12 months. Gingival crevicular fluid was analyzed for matrix metalloprotease (MMP)-8 and interleukin (IL)-1beta levels. Subgingival plaque was taken for assessment of the major bacteria associated with periodontitis. RESULTS: In both groups, PD, AL, and BOP were significantly reduced (p < 0.001). A few significant differences between the groups were found; AL and BOP were significantly better in the test than in the control group at the end of the study (p = 0.020 and 0.009). Periodontopathogens were reduced most in the test group. CONCLUSIONS: A noninferiority of the treatment with azithromycin in comparison with amoxicillin/metronidazole can be stated. The administration of azithromycin could be an alternative to the use of amoxicillin/metronidazole adjunctive to SRP in patients with moderate or severe chronic periodontitis; however, a randomized placebo-controlled multicenter study is needed. CLINICAL RELEVANCE: Application of azithromycin as a single antibiotic for 3 days might be considered as an additional adjunctive antibiotic to SRP in selected patients.
- Freie Schlagwörter (DE)
- Antibiotika, chronische Parodontitis, Zytokine, Parodontopathogenese, Scaling und Rootplaning
- Freie Schlagwörter (EN)
- KEYWORDS: Antibiotics; Chronic periodontitis; Cytokines; Periodontopathogens; Scaling and root planing
- Klassifikation (DDC)
- 610
- GutachterIn
- Prof. Dr. med. dent. Holger A. Jakstat
- Prof. Dr. Dr. Bernd W. Sigusch
- BetreuerIn
- Univ.-Prof. Dr. Dr. h.c. Holger Jentsch
- Den akademischen Grad verleihende / prüfende Institution
- Universität Leipzig, Leipzig
- Förder- / Projektangaben
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa-222327
- Veröffentlichungsdatum Qucosa
- 27.03.2017
- Dokumenttyp
- Dissertation
- Sprache des Dokumentes
- Deutsch
- Inhaltsverzeichnis
Inhaltsverzeichnis 1 Einleitung 7 1.1 Klassifikation der Parodontitiden 7 1.2 Prävalenz der Parodontitis 8 1.3 Parodontales Erregerspektrum 9 2 Aufgabenstellung 12 3 Material und Methode 13 3.1 Erhobene Variablen 15 3.2 Therapie und Nachbehandlung 20 3.3 Biochemische und mikrobiologische Analyse 21 3.3.1 Probenentnahme 21 3.3.2 Analyse 22 3.4 Statistische Auswertung 23 4 Ergebnisse 25 5 Diskussion 33 6 Zusammenfassung 40 7 Literaturverzeichnis 44 8 Anhang 61 9 Publikation 65 10 Lebenslauf 66 11 Danksagung 67 12 Erklärung über die eigenständige Abfassung der Arbeit 68