- AutorIn
- Benjamin Straube
- Ulrike LuekenTechnische Universität Dresden, Institute of Clinical Psychology and Psychotherapy, Germany
- Andreas Jansen
- Carsten Konrad
- Andrew T. Gloster
- Alexander L. Gerlach
- Andreas Ströhle
- André Wittmann
- Bettina Pfleiderer
- Siegfried Gauggel
- Ulrich Wittchen
- Volker Arolt
- Tilo Kircher
- Titel
- Neural Correlates of Procedural Variants in Cognitive-Behavioral Therapy
- Untertitel
- A Randomized, Controlled Multicenter fMRI Study
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-716396
- Quellenangabe
- Psychotherapy and Psychosomatics Erscheinungsort: Basel
Verlag: Karger
Erscheinungsjahr: 2014
Jahrgang: 83
Heft: 4
Seiten: 222-233
E-ISSN: 1423-0348 - Erstveröffentlichung
- 2014
- Abstract (EN)
- Background: Cognitive behavioral therapy (CBT) is an effective treatment for panic disorder with agoraphobia (PD/AG). It is unknown, how variants of CBT differentially modulate brain networks involved in PD/AG. This study was aimed to evaluate the effects of therapist-guided (T+) versus selfguided (T–) exposure on the neural correlates of fear conditioning in PD/AG. Method: In a randomized, controlled multicenter clinical trial in medication-free patients with PD/AG who were treated with 12 sessions of manualized CBT, functional magnetic resonance imaging (fMRI) was used during fear conditioning before (t1) and after CBT (t2). Quality-controlled fMRI data from 42 patients and 42 healthy subjects (HS) were obtained. Patients were randomized to two variants of CBT (T+, n = 22, and T–, n = 20). Results: The interaction of diagnosis (PD/AG, HS), treatment group (T+, T–), time point (t1, t2) and stimulus type (conditioned stimulus: yes, no) revealed activation in the left hippocampus and the occipitotemporal cortex. The T+ group demonstrated increased activation of the hippocampus at t2 (t2 > t1), which was positively correlated with treatment outcome, and a decreased connectivity between the left inferior frontal gyrus and the left hippocampus across time (t1 > t2). Conclusion: After T+ exposure, contingency-encoding processes related to the posterior hippocampus are augmented and more decoupled from processes of the left inferior frontal gyrus, previously shown to be dysfunctionally activated in PD/AG. Linking single procedural variants to neural substrates offers the potential to inform about the optimization of targeted psychotherapeutic interventions.
- Andere Ausgabe
- Link zum Artikel der zuerst in der Zeitschrift 'Psychotherapy and Psychosomatics' erschienen ist
DOI: 10.1159/000359955 - Freie Schlagwörter (DE)
- Panikstörung, Agoraphobie, Kognitiv-behaviorale Therapie, Hippocampus, Funktionelle Magnetresonanztomographie, Angstkonditionierung, Funktionelle Konnektivität
- Freie Schlagwörter (EN)
- Panic disorder, Agoraphobia, Cognitive-behavioral therapy, Hippocampus, Functional magnetic resonance imaging, Fear conditioning, Functional connectivity
- Klassifikation (DDC)
- 610
- Verlag
- Karger, Basel
- Förder- / Projektangaben
- Bundesministerium für Bildung und Forschung
BMBF-Psychotherapie-Forschung
ID: 01GV0615
Technische Universität Dresden, Medizinische Fakultät, Ethikkomission
ID: EK164082006
Rheinisch-Westfälische Hochschule,Aachen, EthikkomissionID: EK 073/07 - Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-716396
- Veröffentlichungsdatum Qucosa
- 05.08.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis