- AutorIn
- Michael Soyka
- Jens StrehleTechnische Universität Dresden, Institute of Clinical Psychology and Psychotherapy, Germany
- Jürgen RehmTechnische Universität Dresden, Institute of Clinical Psychology and Psychotherapy, Germany
- Gerhard Bühringer
- Hans-Ulrich Wittchen
- Titel
- Six-Year Outcome of Opioid Maintenance Treatment in Heroin-Dependent Patients
- Untertitel
- Results from a Naturalistic Study in a Nationally Representative Sample
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-716161
- Quellenangabe
- European Addiction Research Erscheinungsort: Basel
Verlag: Karger
Erscheinungsjahr: 2017
Jahrgang: 23
Heft: 2
Seiten: 97-105
E-ISSN: 1421-9891 - Erstveröffentlichung
- 2017
- Abstract (EN)
- Background: In many countries, the opioid agonists, buprenorphine and methadone, are licensed for maintenance treatment of opioid dependence. Many short-term studies have been performed, but little is known about long-term effects. Therefore, this study described over 6 years (1) mortality, retention and abstinence rates and (2) changes in concomitant drug use and somatic and mental health. Methods: A prevalence sample of n = 2,694 maintenance patients, recruited from a nationally representative sample of n = 223 substitution doctors, was evaluated in a 6-year prospectivelongitudinal naturalistic study. At 72 months, n = 1,624 patients were assessed for outcome; 1,147 had full outcome data, 346 primary outcome data and 131 had died; 660 individuals were lost to follow-up. Results: The 6-year retention rate was 76.6%; the average mortality rate was 1.1%. During follow-up, 9.4% of patients became “abstinent” and 1.9% were referred for drug-free addiction treatment. Concomitant drug use decreased and somatic health status and social parameters improved. Conclusions: The study provides further evidence for the efficacy and safety of maintenance treatment with opioid agonists. In the long term, the number of opioid-free patients is low and most patients are more or less continuously under opioid maintenance therapy. Further implications are discussed.
- Andere Ausgabe
- Link zum Artikel der zuerst in der Zeitschrift 'European Addiction Research' erschienen ist
DOI: 10.1159/000468518 - Freie Schlagwörter (DE)
- Methadon, Buprenorphin, Opioide, Epidemiologie, Opioidabhängigkeit, Ergebnis
- Freie Schlagwörter (EN)
- Methadone, Buprenorphine, Opioids, Epidemiology, Opioid dependence, Outcome
- Klassifikation (DDC)
- 150
- 610
- Verlag
- Karger, Basel
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-716161
- Veröffentlichungsdatum Qucosa
- 04.08.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis