- AutorIn
- Leopold Hentschel Technische Universität Dresden, University Cancer Center, University Hospital Carl Gustav Carus, Dresden, Germany
- Anke RentschTechnische Universität Dresden, University Cancer Center, University Hospital Carl Gustav Carus, Dresden, Germany
- Felicitas LenzTechnische Universität Dresden, Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
- Beate Hornemann
- Jochen Schmitt
- Michael Baumann
- Gerhard Ehninger
- Markus Schuler
- Titel
- A Questionnaire Study to Assess the Value of the Vulnerable Elders Survey, G8, and Predictors of Toxicity as Screening Tools for Frailty and Toxicity in Geriatric Cancer Patients
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-706009
- Quellenangabe
- Oncology Research and Treatment Erscheinungsort: Basel
Verlag: Karger
Erscheinungsjahr: 2016
Jahrgang: 39
Heft: 4
Seiten: 210-216
ISSN: 2296-5270
E-ISSN: 2296-5262 - Erstveröffentlichung
- 2016
- Abstract (EN)
- Background: The aim of this study was to identify an appropriate screening instrument for the identification of frail elderly patients in a tertiary cancer center. In order to improve cancer care for older patients, the use of a geriatric assessment (GA) has been proposed to identify frail patients or those who are at a higher risk for chemotherapy-related toxicities. In busy clinical routine, an appropriate screening instrument could be used to spare time- and resource-consuming application of GA. Patients and Methods: We administered the Vulnerable Elders Survey (VES-13), G8 questionnaire, and Predictors of Toxicity (POT) as well as a GA at the first visit of 84 consecutive patients at a single Comprehensive Cancer Center. Analysis for patients’ characteristics as well as sensitivity, specificity, and positive and negative predictive value (npv) was conducted. Results: The median age of the patients was 73 years (range 63–93 years), 61.9% were male, most (63%) suffered from gastrointestinal tumors, 39.3% had a multiple cancer diagnosis, and 53.6% had metastasis. 30 (35.7%) individuals were classified as ‘frail’ by the GA. Sensitivity of G8 was 38.3%, and the npv was 63.8%. Sensitivity for VES-13 was 57.1%, and npv was 76.3%. Sensitivity of POT was 72.7%, and the npv was 80.6%. Conclusion: For the first time, the VES13, G8, and POT are compared in a sample of older German patients. The POT seems to be a sufficient screening tool to identify frail patients in a tertiary referral cancer center and helps to save time and resources compared with a complete GA.
- Andere Ausgabe
- Link zum Artikel der zuerst in der Zeitschrift 'Oncology Research and Treatment' erschienen ist
DOI: 10.1159/000445365 - Freie Schlagwörter (DE)
- Komorbidität, Fragilität, geriatrische Beurteilung, Screening, Toxizitäten
- Freie Schlagwörter (EN)
- Comorbidity, Frailty, Geriatric assessment, Screening, Toxicities
- Klassifikation (DDC)
- 610
- 350
- Verlag
- Karger, Basel
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-706009
- Veröffentlichungsdatum Qucosa
- 22.05.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis