- AutorIn
- A. Galinowski
- R. Miranda
- H. Lemaitre
- M.-L. Paillère Martinot
- E. Artiges
- H. Vulser
- R. Goodman
- J. Penttilä
- M. Struve
- A. Barbot
- T. Fadai
- L. Poustka
- P. Conrod
- T. Banaschewski
- G. J. Barker
- A. Bokde
- U. Bromberg
- C. Büchel
- H. Flor
- J. Gallinat
- Titel
- Resilience and corpus callosum microstructure in adolescence
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-390535
- Quellenangabe
- Psychological medicine Erscheinungsort: Cambridge
Verlag: Cambridge University Press
Erscheinungsjahr: 2015
Jahrgang: 45
Heft: 11
Seiten: 2285-2294
ISSN: 0033-2917
E-ISSN: 1469-8978 - Erstveröffentlichung
- 2015
- Abstract (EN)
- Background. Resilience is the capacity of individuals to resist mental disorders despite exposure to stress. Little is known about its neural underpinnings. The putative variation of white-matter microstructure with resilience in adolescence, a critical period for brain maturation and onset of high-prevalence mental disorders, has not been assessed by diffusion tensor imaging (DTI). Lower fractional anisotropy (FA) though, has been reported in the corpus callosum (CC), the brain’s largest white-matter structure, in psychiatric and stress-related conditions. We hypothesized that higher FA in the CC would characterize stress-resilient adolescents. Method. Three groups of adolescents recruited from the community were compared: resilient with low risk of mental disorder despite high exposure to lifetime stress (n = 55), at-risk of mental disorder exposed to the same level of stress (n = 68), and controls (n = 123). Personality was assessed by the NEO-Five Factor Inventory (NEO-FFI). Voxelwise statistics of DTI values in CC were obtained using tract-based spatial statistics. Regional projections were identified by probabilistic tractography. Results. Higher FA values were detected in the anterior CC of resilient compared to both non-resilient and control adolescents. FA values varied according to resilience capacity. Seed regional changes in anterior CC projected onto anterior cingulate and frontal cortex. Neuroticism and three other NEO-FFI factor scores differentiated non-resilient participants from the other two groups. Conclusion. High FA was detected in resilient adolescents in an anterior CC region projecting to frontal areas subserving cognitive resources. Psychiatric risk was associated with personality characteristics. Resilience in adolescence may be related to white-matter microstructure.
- Andere Ausgabe
- Link zum Artikel der zuerst in der Zeitschrift 'Psychological medicine' erschienen ist
DOI: 10.1017/S0033291715000239 - Freie Schlagwörter (DE)
- Adoleszenz, Corpus callosum, DAWBA, DTI, NEO-FFI, Belastbarkeit, Traktographie
- Freie Schlagwörter (EN)
- Adolescence, corpus callosum, DAWBA, DTI, NEO-FFI, resilience, tractography
- Klassifikation (DDC)
- 610
- Verlag
- Cambridge University Press, Cambridge
- Förder- / Projektangaben
- European Union IMAGEN
Reinforcementrelated behaviour in normal brain function and psychopathology ID: LSHM-CT-2007-037286 - European Union Innovative Medicine Initiative Project EU-AIMS ID:  115300-2
- Medical Research Council ‘Developmental pathways into adolescent substance abuse’
ID:  93558 - Bundesministerium für Bildung und Forschung NGFN Plus
ID:  FKZ: 01GS08152 - Deutsche Forschungsgemeinschaft 
Reinhart Koselleck Award
ID: SP 383/5-1 - German Ministry of Education and Research ID: 01EV0711
- Paris-Descartes University collaborative-project ADODEP
ID:  ANR-12-SAMA-0004 - Paris-Descartes University collaborative-project ERANET-2012
ID:  AF12- NEUR0008-01-WM2NA - Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-390535
- Veröffentlichungsdatum Qucosa
- 17.04.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis