- AutorIn
- A. Wittmann
- F. Schlagenhauf
- A. Guhn
- U. Lueken
- C. Gaehlsdorf
- M. Stoy
- F. Bermpohl
- T. Fydrich
- B. Pfleiderer
- H. Bruhn
- A. L. Gerlach
- T. Kircher
- B. Straube
- H.-U. Wittchen
- V. Arolt
- A. Heinz
- A. Ströhle
- Titel
- Anticipating agoraphobic situations
- Untertitel
- the neural correlates of panic disorder with agoraphobia
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-390089
- Quellenangabe
- Psychological Medicine Erscheinungsort: Cambridge
Verlag: Cambridge University Press
Erscheinungsjahr: 2014
Jahrgang: 44
Heft: 11
Seiten: 2385-2396
ISSN: 0033-2917
E-ISSN: 1469-8978 - Erstveröffentlichung
- 2014
- Abstract (EN)
- Background: Panic disorder with agoraphobia is characterized by panic attacks and anxiety in situations where escape might be difficult. However, neuroimaging studies specifically focusing on agoraphobia are rare. Here we used functional magnetic resonance imaging (fMRI) with disorder-specific stimuli to investigate the neural substrates of agoraphobia. Method. We compared the neural activations of 72 patients suffering from panic disorder with agoraphobia with 72 matched healthy control subjects in a 3-T fMRI study. To isolate agoraphobia-specific alterations we tested the effects of the anticipation and perception of an agoraphobia-specific stimulus set. During fMRI, 48 agoraphobia-specific and 48 neutral pictures were randomly presented with and without anticipatory stimulus indicating the content of the subsequent pictures (Westphal paradigm). Results: During the anticipation of agoraphobia-specific pictures, stronger activations were found in the bilateral ventral striatum and left insula in patients compared with controls. There were no group differences during the perception phase of agoraphobia-specific pictures. Conclusions: This study revealed stronger region-specific activations in patients suffering from panic disorder with agoraphobia in anticipation of agoraphobia-specific stimuli. Patients seem to process these stimuli more intensively based on individual salience. Hyperactivation of the ventral striatum and insula when anticipating agoraphobiaspecific situations might be a central neurofunctional correlate of agoraphobia. Knowledge about the neural correlates of anticipatory and perceptual processes regarding agoraphobic situations will help to optimize and evaluate treatments, such as exposure therapy, in patients with panic disorder and agoraphobia.
- Andere Ausgabe
- Link zum Artikel der zuerst in der Zeitschrift 'Psychological Medicine' erschienen ist
DOI: 10.1017/S0033291713003085 - Freie Schlagwörter (DE)
- Agoraphobie, Vorfreude, funktionelle Magnetresonanztomographie, Insula, Panik, ventrales Striatum, westphales Paradigma
- Freie Schlagwörter (EN)
- Agoraphobia, anticipation, functional magnetic resonance imaging, insula, panic, ventral striatum, Westphal paradigm
- Klassifikation (DDC)
- 610
- Verlag
- Cambridge University Press, Cambridge
- Förder- / Projektangaben
- Ministerium für Bildung und Forschung
BMBF-Psychotherapie-Forschung
ID: 01GV0612
Technischen Universität Dresden, Medizinische Fakultät, EthikkomissionRCT-Projekt
ID: EK 164082006
Rheinisch-Westfälische Hochschule Aachen, Ethikkomission NeurobildgebungskomponenteID: EK 073/07
Land Berlin, Ethikkomissionexperimentelle PharmakologiestudieID: EudraCT: 2006-00-4860-29 - Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-390089
- Veröffentlichungsdatum Qucosa
- 11.06.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis