- AutorIn
- Claudia Rentsch Technische Universität Dresden, Department of Trauma and Reconstructive Surgery, University Hospital Carl Gustav Carus Dresden, Germany#Technische Universität Dresden, Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus Dresden, Germany
- Wolfgang SchneidersTechnische Universität Dresden, Department of Trauma and Reconstructive Surgery, University Hospital Carl Gustav Carus Dresden, Germany#Technische Universität Dresden, Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus Dresden, Germany
- Ricarda HessTechnische Universität Dresden, Max Bergmann Center of Biomaterials, Dresden, Germany
- Barbe Rentsch
- Ricardo Bernhardt
- Kathrin Spekl
- Konrad Schneider
- Dieter Scharnweber
- Achim Biewener
- Stefan Rammelt
- Titel
- Healing properties of surface-coated polycaprolactone-co-lactide scaffolds
- Untertitel
- A pilot study in sheep
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-356930
- Quellenangabe
- Journal of Biomaterials Applications Erscheinungsort: Thousand Oaks
Verlag: Sage
Erscheinungsjahr: 2014
Jahrgang: 28
Heft: 5
Seiten: 654-666
E-ISSN: 1530-8022 - Erstveröffentlichung
- 2014
- Abstract (EN)
- The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds were implanted into a 3 cm sheep tibia critical size defect for 3 or 12 months (n¼5 each). Bone healing was estimated by quantification of bone volume in the defects on computer tomography and microcomputer tomography scans, plain radiographs, biomechanical testing as well as by histological evaluations. New bone formation occurred at the proximal and distal ends of the tibia in both groups. The current pilot study revealed a mean new bone formation of 63% and 172% after 3 and 12 months, respectively. The bioactive, surface coated, highly porous three-dimensional polycaprolactone-co-lactide scaffold stack itself acted as a guide rail for new bone formation along and into the implant. These preliminary data are encouraging for future experiments with a larger group of animals.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift 'Journal of Biomaterials Applications' erschienen ist.
DOI: 10.1177/0885328212471409 - Freie Schlagwörter (DE)
- Polycaprolacton-Co-Lactidgerüst, Kollagen Typ I und Chondroitinsulfat, Schafe, Schienbeindefekt, Knochenheilung
- Freie Schlagwörter (EN)
- Polycaprolactone-co-lactide scaffold, collagen type I and chondroitin sulfate, sheep, tibia defect, bone healing
- Klassifikation (DDC)
- 610
- Verlag
- Sage, London
- Förder- / Projektangaben
- Deutsche Forschungsgemeinschaft ID: TRR 67
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-356930
- Veröffentlichungsdatum Qucosa
- 11.10.2019
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis