Literatur
Holman RR, Sourij H, Califf RM (2014) Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes. Lancet 383(9933):2008–2017. https://doi.org/10.1016/S0140-6736(14)60794-7
Meinert CL, Knatterud GL, Prout TE, Klimt CR (1970) A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results. Diabetes 19(suppl):789–830
Bethel MA, Sourij H (2012) Impact of FDA guidance for developing diabetes drugs on trial design: from policy to practice. Curr Cardiol Rep 14(1):59–69
Green JB, Bethel MA, Armstrong PW, Buse JB, Engel SS, Garg J et al (2015) Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. N Engl J Med 373(3):232–242
White WB, Zannad F (2014) Saxagliptin, alogliptin, and cardiovascular outcomes. N Engl J Med 370(5):484
Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B et al (2013) Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 369(14):1317–1326
Buse JB, Bethel MA, Green JB, Stevens SR, Lokhnygina Y, Aschner P et al (2017) Pancreatic safety of sitagliptin in the TECOS study. Diabetes Care 40(2):164–170
Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Kober LV et al (2015) Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 373(23):2247–2257
Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JF, Nauck MA et al (2016) Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 375(4):311–322
Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jodar E, Leiter LA et al (2016) Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 375(19):1834–1844
Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, Chan JC, Choi J, Gustavson SM, Iqbal N, Maggioni AP, Marso SP, Öhman P, Pagidipati NJ, Poulter N, Ramachandran A, Zinman B, Hernandez AF, EXSCEL Study Group (2017) Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes. N Engl J Med 377(13):1228–1239. https://doi.org/10.1056/NEJMoa1612917
Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S et al (2015) Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373(22):2117–2128
Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N et al (2017) Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 377(7):644–657
Marso SP, McGuire DK, Zinman B, Poulter NR, Emerson SS, Pieber TR et al (2017) Efficacy and safety of degludec versus glargine in type 2 diabetes. N Engl J Med. https://doi.org/10.1056/NEJMoa1615692
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
C. Sourij hat keine Interessenskonflikte. H. Sourij erhielt „unrestricted research grants“ von MSD, Böhringer Ingelheim, NovoNordisk, Sanofi und Astra Zeneca. Er ist beratend und als Sprecher für Astra Zencea, Böhringer Ingelheim, Eli Lilly, MSD, NovoNordisk und Sanofi tätig.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
Rights and permissions
About this article
Cite this article
Sourij, C., Sourij, H. Kardiovaskuläre Outcome-Studien in der Diabetologie – ein Überblick. J. Klin. Endokrinol. Stoffw. 10, 119–121 (2017). https://doi.org/10.1007/s41969-017-0013-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s41969-017-0013-4