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Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands

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Abstract

This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody. Higher GLUT-1 immunoexpression was observed in the MECs compared to PAs and ACCs (p = 0.022). Mean number of microvessels was 66.5 in MECs, 40.4 in PAs, and 21.2 in ACCs (p < 0.001). GLUT-1 expression and angiogenic index showed no significant correlation in the tumors studied. Results suggest that differences in biological behavior of the studied tumors are related to GLUT-1. Benign and malignant salivary gland tumors differ in the angiogenic index; however, angiogenesis may be independent of the tumor cell’s metabolic demand.

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Authors and Affiliations

  1. Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Lélia Batista de Souza, Lucileide Castro de Oliveira, Maria Luiza Diniz de Sousa Lopes, Leão Pereira Pinto & Lélia Maria Guedes Queiroz

  2. Department of Pathology and Forensic Medicine, Federal University of Amazonas, Manaus, AM, Brazil

    Lucileide Castro de Oliveira

  3. State University of Paraíba, Campina Grande, PB, Brazil

    Cassiano Francisco Weege Nonaka

  4. Departamento de Odontologia, Universidade Federal do Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil

    Lélia Batista de Souza

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  1. Lélia Batista de Souza
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Correspondence to Lélia Batista de Souza.

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The authors declare that they have no conflict of interest.

Ethical approval

This study was performed in accordance with the ethical standards of the Ethics Committee of the Federal University of Rio Grande do Norte (Permit No. 375/2011) and with the 1964 Helsinki declaration and its later amendments.

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Informed consent was obtained from all individual participants included in the study.

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de Souza, L.B., de Oliveira, L.C., Nonaka, C.F.W. et al. Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands. Eur Arch Otorhinolaryngol 274, 2549–2556 (2017). https://doi.org/10.1007/s00405-017-4530-y

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  • DOI: https://doi.org/10.1007/s00405-017-4530-y

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