Objective. To study the dynamics of EEG spectral characteristics during transcranial magnetic stimulation (TMS) in therapeutically refractory depression. Materials and methods. The study included 32 patients with depression in the framework of recurrent depressive and bipolar affective disorders. TMS was performed and EEG recordings made on the background of ineffective thymoanaleptic treatment at reduced doses. TMS was applied at the projection of the left prefrontal cortex. Treatment courses consisted of 15 sessions with 100% threshold intensity. In each session, patients received 20 cycles of stimuli at a frequency of 15 Hz, duration 6 sec, separated by intervals of 60 sec. EEG recordings were made using a Neiro-KM instrument (Russian-made) with a bandpass of 0.5–45 Hz and a time constant of 0.3 sec before and after courses of TMS. EEG spectral analysis was by fast Fourier transformation with averaging of at least 30 2-sec epochs followed by mapping using the Brainsys system (made in Russia). Results and conclusions. Post-TMS EEG changes were generalized in nature and involved rearrangement of all frequency ranges in brain electrical activity. However, the greatest changes were seen at the α rhythm frequencies: the index increased in all cortical zones, though the greatest increase in α activity was seen in the occipital areas of the cortex, forming an α rhythm focus in these zones.
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References
M. George, T. Schlaepfer, et al., “Brain stimulation treatments for depression,” World J. Biol. Psychiatry, 15, 167–168 (2014); doi: 10.3109/15622975.2013.869619.
T. Burt, S. Lisanby, and H. Sackeim, “Neuropsychiatric applications of transcranial magnetic stimulation,” Int. J. Neuropsychopharmacol., 5, No. 1, 73–103 (2002); doi: 10.1017/s1461145702002791.
E. E. Tsukarzi, “Current methods in brain stimulation: progress and potential,” Sots. Klin. Psikhiatr., 23, No. 1, 93–99 (2013).
S. A. Il’in, E. E. Tsukarzi, and S. N. Mosolov, “Comparative efficacy and tolerability of cyclic transcranial magnetic stimulation and ECT in protracted therapeutically resistant depression,” Sots. Klin. Psikhiatr., No. 2, 73–80 (2008).
S. G. Kapiletti, T. S. Mel’nikova, E. E. Tsukarzi, and S. N. Mosolov, “Dynamics of autonomic regulation in transcranial magnetic stimulation in patients with depression,” Sots. Klin. Psikhiatr., No. 2, 72–75 (2001).
N. V. Maslennikov, E. E. Tsukarzi, and S. N. Mosolov, “Depression in schizophrenia: assessment of cognitive functions during treatment with transcranial magnetic stimulation,” Sots. Klin. Psikhiatr., 23, No. 1, 5–11 (2013).
N. V. Maslennikov, E. E. Tsukarzi, and S. N. Mosolov, “Efficacy of transcranial magnetic stimulation (TMS) in depression in patients with schizophrenia,” Obozr. Psikhiatr. Med. Psikhol., 4 (2009).
S. G. Kapiletti, E. E. Tsukarzi, and S. N. Mosolov, “Transcranial magnetic stimulation in the treatment of obsessive-compulsive disorders,” Sots. Klin. Psikhiatr., No. 1, 42–47 (2008).
O. D. Pugovkina, E. E. Tsukarzi, A. B. Kholmogorova, and S. N. Mosolov, “Dynamics of cognitive functions in patients with refractory depression using electroconvulsive therapy and transcranial magnetic stimulation,” Sots. Klin. Psikhiatr., No. 2, 47–52 (2006).
D. Avery, K. Isenberg, S. Sampson, et al., “Transcranial magnetic stimulation in the acute treatment of major depressive disorder: clinical response in an open-label extension trial,” J. Clin. Psychiatry, 69, No. 3, 441–451 (2008); doi: 10.4088/jcp.v69n0315.
B. Belmaker, P. Fitzgerald, et al., “Managing the risks of repetitive transcranial stimulation,” CNS Spectr., 8, No. 7, 89 (2003).
N. V. Maslennikov, E. E. Tsukarzi, and S. N. Molotov, “Transcranial magnetic stimulation in the treatment of depression and negative symptomatology in schizophrenia,” Psikh. Zdorov., No. 1, 39–44 (2011).
I. V. Potapov, E. E. Tsukarzi, and S. N. Mosolov, “Use of transcranial magnetic stimulation in refractory verbal hallucinations,” Obozr. Psikhiatr. Med. Psikhol., No. 1, 23–34 (2014).
V. Di Lazzaro U. Ziemann, and R. Lemon, “State of the art: Physiology of transcranial motor cortex stimulation,” in: Brain Stimu lation: Basic, Translational and Clinical Research in Neuromo dulation, 1, No. 4, 345–362 (2008); doi: 10.1016/j.brs.2008.07.004.
E. Higgins and M. George, Brain Stimulation Therapies for Clinicians, American Psychiatric Press, Washington (2008).
R. Hoffman and I. Cavus, “Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders,” Am. J. Psychiatry, 159, No. 7, 1093–1102 (2002).
Z. Nahas, C. Teneback, A. Kozel, et al., “Brain effects of TMS delivered over prefrontal cortex in depressed adults: role of stimulation frequency and coil-cortex distance,” J. Neuropsychiatry Clin. Neurosci., 13, No. 4, 459–470 (2001); doi: 10.1176/appi.neuropsych.13.4.459.
A. Pascual-Leone, J. Gates, and A. Dhuna, “Induction of speech arrest and counting errors with rapid-rate transcranial magnetic stimulation,” Neurology, 41, 697–702 (1991); doi: 10.1212/wnl.41.5.697.
M. Szuba, J. O’Reardon, and D. Evans, “Physiological effects of electroconvulsive therapy and transcranial magnetic stimulation in major depression,” Depress. Anxiety, 12, No. 3, 170–177 (2000); doi: 10.1002/1520-6394(2000)12:3<170::aid-da9>3.0.co;2-m.
U. Ziemann, W. Paulus, M. Nitsche, et al., “Consensus: Motor cortex plasticity protocols,” in: Brain Stimulation: Basic, Translational and Clinical Research in Neuromodulation, 1, No. 3, 164–182 (2008); doi: 10.1016/j.brs.2008.06.006.
T. S. Mel’nikova and I. A. Lapin, “EEG coherence analysis in depressive disorders of different origins,” Sots. Klin. Psikhiatr., No. 3, 27–32 (2008).
N. E. Sviderskaya, Synchronous Electrical Activity of the Brain and Mental Processes, Nauka, Moscow (1987).
C. Herrman and T. Demiralp, “Human EEG gamma oscillations in neuropsychiatric disorders,” Clin. Neurophysiol., 116, No. 12, 2719–2733 (2005); doi: 10.1016/j.clinph.2005.07.007.
P. Sauseng and W. Klimesch, “What does phase information of oscillatory brain activity tell us about cognitive processes?” Neurosci. Biobehav. Rev., 32, 1001–1013 (2008); doi: 10.1016/j.neubiorev.2008. 03.014.
A. Von Stain and J. Sarnthein, “Different frequencies for different scale of cortical integration: from local gamma to long range alpha/theta synchronization,” Int. J. Psychophysiol., No. 3, 301–314 (2000); doi: 10.1016/s0167-8760(00)00172-0.
N. N. Danilova, “The role of high-frequency rhythms in brain electrical activity in supporting mental processes,” Psikhol. Zh. VShE, 3, No. 2, 62–72 (2006).
L. B. Ivanov, N. N. Strekalina, N. Yu. Chulkova, and A. V. Budkevich, “Variants of the spatial distribution of α activity depending on the type of affective disorder,” Funktsional. Diagn., No. 1, 41–49 (2009).
V. M. Kamenskaya and E. S. Mikhailova, “Studies of the ratio of electroencephalographic and autonomic parameters in stress situations in patients with different types of depression,” Zh. Nevrol. Psikhiat., No. 9, 57–62 (1982).
A. A. Fingelkurts, A. A. Fingelkurts, H. Rytsälä, et al., “Impaired functional connectivity at EEG alpha and theta frequency bands in major depression,” Hum. Brain Mapp., 28, No. 3, 247–261 (2007); doi: 10.1002/hbm.20275.
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 115, No. 8, Iss. I, pp. 35–41, August, 2015.
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Mel’nikova, T.S., Tsukarzi, E.E., Kovalev, A.V. et al. Dynamics of Electroencephalogram Spectral Characteristics during Use of Transcranial Magnetic Stimulation in Patients with Refractory Depression. Neurosci Behav Physi 47, 281–287 (2017). https://doi.org/10.1007/s11055-017-0394-2
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DOI: https://doi.org/10.1007/s11055-017-0394-2