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Part 2: biocompatibility evaluation of hydroxyapatite-based clinoptilolite and Al2O3 composites

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Abstract

The biocompatibility of clinoptilolite/alumina/bovine hydroxyapatite (Cp - A12O3 - BHA) composite, at different ratio obtained by powder pressing process, were investigated studying the behavior of osteosarcoma (SAOS-2) cells. The biocompatibility was examined by means of cytotoxicity and cytocompatibility tests. The structure and morphology of bioceramic composites were studied by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) technique. The results showed that these materials have no toxic effects. The natural composite that fabricated in this study may be a promising approach for bone-engineering applications.

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Acknowledgements

This study was supported by Istanbul University, Scientific Research Projects Coordination Unit, Project No: 29071.

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Authors and Affiliations

  1. Biomedical Engineering, Ph.D. Program, Institute of Graduate Studies in Science and Engineering, Istanbul University, Istanbul, Turkey

    C. Kalkandelen & A. Akan

  2. Vocational School of Technical Sciences, Biomedical Devices Technology Department, Istanbul University, Istanbul, Turkey

    C. Kalkandelen

  3. Istanbul Faculty of Physiology, Istanbul University, Capa, Istanbul, Turkey

    M. Suleymanoglu & S. E. Kuruca

  4. Department of Biomedical Engineering, Faculty of Engineering and Architecture, Izmir Katip Celebi University, Izmir, 35620, Turkey

    A. Akan

  5. Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey

    F.N. Oktar

  6. Advanced Nanomaterials Research Laboratory, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey

    F.N. Oktar & O. Gunduz

  7. Department of Metallurgy and Materials Engineering, Faculty of Technology, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey

    O. Gunduz

Authors
  1. C. Kalkandelen
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  2. M. Suleymanoglu
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  3. S. E. Kuruca
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  4. A. Akan
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  5. F.N. Oktar
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  6. O. Gunduz
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Correspondence to C. Kalkandelen.

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Kalkandelen, C., Suleymanoglu, M., Kuruca, S.E. et al. Part 2: biocompatibility evaluation of hydroxyapatite-based clinoptilolite and Al2O3 composites. J Aust Ceram Soc 53, 217–223 (2017). https://doi.org/10.1007/s41779-017-0027-9

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  • DOI: https://doi.org/10.1007/s41779-017-0027-9

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