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Design and synthesis of three series of novel antitumor–azo derivatives

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Abstract

Three new series of thiazoles, quinolones, and thiazolidinones merged with benzimidazole, benzoxazole, and benzothiazole nuclei were synthesized. The compounds were subjected to Infrared, 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, mass spectrometry, and elemental analyses. Cytotoxic activity of compounds were evaluated against breast (MCF-7) and colon (HCT-116) cell lines. Seven of the compounds had IC50 values between 0.0112 and 0.0198 µM and are hence more potent than the reference drug doxorubicin (IC50 = 0.0084 and 0.0088 µM against MCF-7 and HCT-116, respectively).

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Acknowledgements

The authors would like to thank NMR Lab members, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt for their helping in analysing all the required samples using proton NMR and DEPT-Q techniques.

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  1. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt

    Phoebe F. Lamie & John N. Philoppes

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  1. Phoebe F. Lamie
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  2. John N. Philoppes
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Correspondence to Phoebe F. Lamie.

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Lamie, P.F., Philoppes, J.N. Design and synthesis of three series of novel antitumor–azo derivatives. Med Chem Res 26, 1228–1240 (2017). https://doi.org/10.1007/s00044-017-1839-4

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