References
Boivin, S., Cusack, S., Ruigrok, R.W.H., and Hart, D.J. (2010). Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms. J Biol Chem 285, 28411–28417.
Mehle, A., and Doudna, J.A. (2009). Adaptive strategies of the influenza virus polymerase for replication in humans. Proc Natl Acad Sci USA 106, 21312–21316.
Neumann, G., and Kawaoka, Y. (2006). Host range restriction and pathogenicity in the context of influenza pandemic. Emerg Infect Dis 12, 881–886.
World Health Organization. (2010). WHO recommendations for the post-pandemic period http://www.who.int/csr/disease/swineflu/notes/briefing_20100810/en.
Zhang, W., Shi, Y., Qi, J., Gao, F., Li, Q., Fan, Z., Yan, J., and Gao, G.F. (2013). Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution. J Virol 87, 5949–5958.
Acknowledgements
This word was supported by the National Mega-projects for Infectious Diseases (2014ZX10004002-002 to Yuelong Shu), the National Key Research and Development Program of China (2016YFC1200201 to Yuelong Shu), and the National Nature Science Foundation of China (81601758 to Wenfei Zhu).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chen, Y., Zhu, W., Bai, T. et al. The substitution V379I in PA protein attenuates the pathogenicity of influenza A (H1N1) pdm09 viruses in mice. Sci. China Life Sci. 60, 1044–1046 (2017). https://doi.org/10.1007/s11427-016-9018-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-016-9018-8