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The effect of acute aerobic exercise on hemostasis in obstructive sleep apnea

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

Individuals with obstructive sleep apnea (OSA) have an altered hemostatic balance; however, the exercise response is less described. The purpose of this study is to determine the hemostatic response after acute aerobic exercise in obstructive sleep apnea.

Methods

Eighteen males (nine OSA vs. nine controls) were recruited from the university and local community. Individuals with evidence of cardiovascular, pulmonary, or metabolic disease were excluded. An apnea-hypopnea index (AHI) of >5 was a criterion for OSA. Subjects performed a treadmill exercise test at 35 and 70% predicted VO2 reserve during the morning hours. Pre-exercise blood samples were obtained after 15 min supine rest and within 2 min following exercise. Repeated measures ANOVA were performed for factor VIII antigen, tissue plasminogen activator (tPA) antigen, tPA activity, and PAI-1 activity. Correlational analysis compared resting and post-exercise hemostatic factors with age, BMI, and AHI.

Results

Mean AHI was 13.00 ± 12.6. No exercise × condition interactions were observed for hemostatic markers. There was a main effect for exercise in factor VIII, tPA antigen, and tPA activity in both groups. PAI-1 activity tended to be elevated in OSA (145%) compared to controls which remained after exercise (205%) (P = 0.05). Post-exercise FVIII/Ag correlated with BMI (r = 0.52), while resting tPA/Ag correlated with AHI (r = 0.49) and age (r = 0.50).

Conclusion

The hemostatic response after acute aerobic exercise is unaffected in mild OSA, although PAI-1 activity seems to be elevated, reducing fibrinolytic potential. BMI seems to correlate with FVIII/Ag, while tPA/Ag is associated with AHI and age.

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Acknowledgments

This research was supported by a grant from the ResMed Foundation in La Jolla, CA.

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Authors and Affiliations

  1. Department of Kinesiology, James Madison University, Harrisonburg, VA, 22807, USA

    Ryan A. Martin, Courtney Strosnider, Gabrielle Giersch, Christopher J. Womack & Trent A. Hargens

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  1. Ryan A. Martin
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  2. Courtney Strosnider
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  3. Gabrielle Giersch
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  5. Trent A. Hargens
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Correspondence to Trent A. Hargens.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest in the subject matter discussed in this manuscript.

Human and animal rights and informed consent

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All research procedures were approved by the Institutional Review Boards of James Madison University and Sentara Rockingham Memorial Hospital. Informed consent was obtained from all individual participants included in the study.

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The ResMed Foundation provided financial support in the form of research grant funding. The sponsor had no role in the design or conduct of this research.

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Martin, R.A., Strosnider, C., Giersch, G. et al. The effect of acute aerobic exercise on hemostasis in obstructive sleep apnea. Sleep Breath 21, 623–629 (2017). https://doi.org/10.1007/s11325-017-1477-6

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  • DOI: https://doi.org/10.1007/s11325-017-1477-6

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