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A novel marker in acute central serous chorioretinopathy: thiol/disulfide homeostasis

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Abstract

Purpose

The aim of this study was to compare dynamic thiol/disulfide homeostatic status in acute central serous chorioretinopathy (CSCR) patients by using a novel and automated assay determining dynamic thiol/disulfide homeostasis.

Methods

Fifty-one patients with acute CSCR (study group) and 65 healthy individuals (control group) were enrolled in this study. Diagnosis of acute CSCR was made clinically and using spectral-domain RTVue OCT (optical coherence tomography) (Optovue, Fremont, CA). Fluorescein angiography confirmed the diagnosis of acute CSCR in all subjects. Total thiol, native thiol, disulfide amount, and native thiol/disulfide ratio (TDR) were calculated in the blood samples.

Results

Mean total thiol, native thiol, and native TDR values were lower in patients with acute CSCR (364.2 ± 14.1, 326.4 ± 13.2, 17.14 ± 1.9, respectively) than in healthy eyes (441.2 ± 16.3, 398.5 ± 16.4, 22.70 ± 2.15, respectively; mean total thiol, p = 0.017; native thiol, p = 0.011; native TDR, p = 0.031).

Conclusions

Total thiol, native thiol, and native TDR were significantly lower statistically in patients with acute CSCR when compared with healthy controls.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Ankara Atatürk Education and Research Hospital, Ankara, Turkey

    Hasan Altinkaynak, Mehtap Caglayan, Mücella Arıkan Yorgun & Nilay Yuksel

  2. Department of Ophthalmology, World Eye Hospital, Ankara, Turkey

    Piraye Zeynep Kurkcuoglu

  3. Department of Biochemistry, Yıldırım Beyazıt University, Ankara Atatürk Education and Research Hospital, Ankara, Turkey

    Cemile Koca

  4. Ulucanlar Eye Education and Research Hospital, Ankara, Turkey

    Pınar Kosekahya

  5. Department of Ophthalmology, Yıldırım Beyazıt University, Ankara Atatürk Education and Research Hospital, Ankara, Turkey

    Yasin Toklu

Authors
  1. Hasan Altinkaynak
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  2. Piraye Zeynep Kurkcuoglu
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  3. Mehtap Caglayan
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Correspondence to Hasan Altinkaynak.

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The authors declare no financial or proprietary interests.

Ethical approval

The study protocol followed the principles in the Declaration of Helsinki.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Altinkaynak, H., Kurkcuoglu, P.Z., Caglayan, M. et al. A novel marker in acute central serous chorioretinopathy: thiol/disulfide homeostasis. Int Ophthalmol 38, 175–181 (2018). https://doi.org/10.1007/s10792-017-0444-3

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  • DOI: https://doi.org/10.1007/s10792-017-0444-3

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