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T1 mapping using saturation recovery single-shot acquisition at 3-tesla magnetic resonance imaging in hypertrophic cardiomyopathy: comparison to late gadolinium enhancement

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Abstract

Purpose

We evaluated the T1 values of segments and slices and the reproducibility in healthy controls, using saturation recovery single-shot acquisition (SASHA) at 3T magnetic resonance imaging. Moreover, we examined the difference in T1 values between hypertrophic cardiomyopathy (HCM) and healthy controls, and compared those with late gadolinium enhancement (LGE).

Materials and methods

Twenty-one HCM patients and 10 healthy controls underwent T1 mapping before and after contrast administration. T1 values were measured in 12 segments.

Results

Native T1 values were significantly longer in HCM than in healthy controls [1373 ms (1312–1452 ms) vs. 1279 ms (1229–1326 ms); p < 0.0001]. Even in HCM segments without LGE, native T1 values were significantly longer than in healthy control segments [1366 ms (1300–1439 ms) vs. 1279 ms (1229–1326 ms); p < 0.0001]. Using a cutoff value of 1327 ms for septal native T1 values, we differentiated between HCM and healthy controls with 95% sensitivity, 90% specificity, 94% accuracy, and an area under the curve of 0.95.

Conclusions

Native T1 values using a SASHA at 3T could differentiate HCM from healthy controls. Moreover, native T1 values have the potential to detect abnormal myocardium that cannot be identified adequately by LGE in HCM.

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Authors and Affiliations

  1. Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan

    Ryo Ogawa, Tomoyuki Kido, Masashi Nakamura, Teruhito Kido, Akira Kurata, Masao Miyagawa & Teruhito Mochizuki

  2. Department of Cardiovascular Internal Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan

    Teruyoshi Uetani & Akiyoshi Ogimoto

Authors
  1. Ryo Ogawa
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  2. Tomoyuki Kido
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  3. Masashi Nakamura
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  4. Teruhito Kido
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Correspondence to Ryo Ogawa.

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The authors declare that there is no conflict of interest.

The study design was approved by the appropriate ethics review boards.

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Ogawa, R., Kido, T., Nakamura, M. et al. T1 mapping using saturation recovery single-shot acquisition at 3-tesla magnetic resonance imaging in hypertrophic cardiomyopathy: comparison to late gadolinium enhancement. Jpn J Radiol 35, 116–125 (2017). https://doi.org/10.1007/s11604-017-0611-5

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  • DOI: https://doi.org/10.1007/s11604-017-0611-5

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