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In vivo metabolism of aminopyrine by the larvae of the helminthHeligmosomoides polygyrus

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Abstract

The in vivo N-dealkylation of [13C-2]-labeled aminopyrine by the L1–L2 larvae ofHeligmosomoides polygyrus was demonstrated by the use of a sensitive gas chromatography-mass spectrometry method. This is the first evidence for the possible existence of a cytochrome P-450-dependent activity in helminths.

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Authors and Affiliations

  1. Station de Pathologie Aviaire et de Parasitologie, Unité d'Helminthologie, Centre de Recherches de Tours, Institut National de la Recherche Agronomique, F-37380, Nouzilly, France

    Dominique Kerboeuf & Denis Soubieux

  2. Laboratoire d'Etudes Analytiques et Cinétiques du Médicament, Institut des Sciences Pharmaceutiques et Biologiques de Lyon, 8 Avenue Rockefeller, 69373, Lyon Cedex 08, France

    Roger Guilluy & Jean-Louis Brazier

  3. Institut National de la Recherche Agronomique, Unité de Toxicologie Métabolique et d'Ecotoxicologie, Ecole Nationale Vétérinaire de Lyon, BP83, 69280, Marcy l'Etoile, France

    Jean-Louis Rivière

Authors
  1. Dominique Kerboeuf
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  2. Denis Soubieux
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  3. Roger Guilluy
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  4. Jean-Louis Brazier
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  5. Jean-Louis Rivière
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Kerboeuf, D., Soubieux, D., Guilluy, R. et al. In vivo metabolism of aminopyrine by the larvae of the helminthHeligmosomoides polygyrus . Parasitol Res 81, 302–304 (1995). https://doi.org/10.1007/BF00931534

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  • DOI: https://doi.org/10.1007/BF00931534

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