Summary
The tumour-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) interfers with nerve cell production in Hydra when applied to the animals' culture medium. Precursor cells exposed to 0.2 nM TPA during the first half of their S-phase are prevented from differentiating into nerve cells. Precursor cells which start their S-phase following a treatment with TPA give rise to nerve cells. The frequency is higher than in untreated control animals.
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References
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Greger, V., Berking, S. Nerve cell production in Hydra is deregulated by tumour-promoting phorbol ester. Roux's Arch Dev Biol 200, 234–236 (1991). https://doi.org/10.1007/BF00361343
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DOI: https://doi.org/10.1007/BF00361343