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Dinucleotide repeat polymorphism in the proteolipoprotein (PLP) gene

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Abstract

We report a dinucleotide polymorphism in the first intron of the proteolipid protein (PLP) gene with a heterozygosity frequency of 0.69 useful for molecular analysis of families with X-linked neurologic disorders characterized by dysmyelination of the central nervous system, Pelizaeus-Merzbacher Disease (PMD) and X-linked Spastic Paraplegia (SPG2).

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References

  • Boespflug-Tanguy O (1994) Genetic homogeneity of Pelizaeus-Merzbacher Disease: tight linkage to the proteolipoprotein locus in 16 affected families. Am J Hum Genet 55:461–467

    Google Scholar 

  • Saugier-Weber P (1994) X-linked spastic paraplegia and Peliaeus-Merzbacher disease are allelic disorders at the proteolipid protein locus. Nature Genet 6:257–262

    Google Scholar 

  • Williamson R (1991) Report of the DNA committee and catalogues of cloned and mapped genes, markers formatted for PCR and DNA polymorphisms. Cytogenet Cell Genet 58:1643

    Google Scholar 

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Authors and Affiliations

  1. INSERM U384, Faculte de Médecine, 63000, Clermont-Ferrand Cedex, France

    Corinne Mimault, Fabrice Cailloux, Geneviève Giraud, Bernard Dastugue & Odile Boespflug-Tanguy

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  1. Corinne Mimault
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  2. Fabrice Cailloux
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  3. Geneviève Giraud
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  4. Bernard Dastugue
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  5. Odile Boespflug-Tanguy
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Mimault, C., Cailloux, F., Giraud, G. et al. Dinucleotide repeat polymorphism in the proteolipoprotein (PLP) gene. Hum Genet 96, 236 (1995). https://doi.org/10.1007/BF00207388

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  • DOI: https://doi.org/10.1007/BF00207388

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