Abstract
Objectives
The primary purpose of this study was to determine whether both zoledronic acid (ZA) and denosumab (Dmab) equally suppress bone remodeling of the normal mandible, and the secondary purpose was to determine the influence of ZA and Dmab on other normal bones.
Methods
18F-sodium fluoride-positron-emission-tomography (18F-NaF-PET) was used to perform quantitative analysis of the bone metabolism in various parts. The end points of the study were the mean standardized uptake value (SUV) of each member of the ZA group (n = 9), the Dmab group (n = 16), and the Control group (n = 23).
Results
The SUV at the thoracic vertebrae in the ZA group were significantly lower than those of the Dmab and Control group (p < 0.05) In addition, the mean SUVs of the cervical vertebrae in the ZA group were significantly lower than those in the Control group (p < 0.05). There was no significant difference among ZA, Dmab and Control group in the other sites. There was no significant difference between the Dmab and Control groups at all sites.
Conclusions
The remodeling of mandible was not suppressed due to the treatment with anti-resorptive agents. Differences in the mechanisms of action between the BP and Dmab caused the specificity of the effect on the metabolism of normal bone.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (the Kagawa University Ethical Committee (2020-#122)) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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Fushimi, M., Ohbayashi, Y., Nakai, F. et al. The effect of zoledronic acid and denosumab on the mandible and other bones: a 18F-NaF-PET study. Oral Radiol 38, 594–600 (2022). https://doi.org/10.1007/s11282-022-00594-2
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DOI: https://doi.org/10.1007/s11282-022-00594-2