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Clear Cell Odontogenic Carcinoma a Systematic Review

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Abstract

Clear cell Odontogenic Carcinoma (CCOC) is an uncommon malignant odontogenic tumor (MOT). It is the fifth most common MOT. A systematic review is presented of reported cases, case series and retrospective studies of CCOC, to determine trends in presentation, diagnostic features, treatment, and patient outcome. Searches of detailed databases were carried out to identify papers reporting CCOC. The variables were demographics, patient symptoms, tumor location, histopathological findings, immunohistochemical studies, treatment, follow-up, and recurrence. 117 cases were identified; CCOC was most frequently seen in mature females 65% (n = 76). The total average age was 55.4 with a range from 17 to 89 years, for females 56.4 and males 53.6 years. The mean size was 3.41 cm. The most common location was in the mandibular body 36.2% (n = 42), followed by the anterior mandible 23.3% (n = 27). The most common clinical presentation was a swelling 80.4% (n = 74), and the main symptom was pain 41.3% (n = 31), followed by painless lesion 24% (n = 18). The most common Immunohistochemistry positive expression was CK19, EMA, and CEA, and for special staining periodic acid Shiff (PAS); 97% of cases were treated surgically. The average follow-up was 30.3 months, and recurrence was reported in 52.4% of the cases. Conclusion: CCOC shows a strong predilection for the body and anterior mandible, and females are more frequently affected. CCOCs can be painful and the principle clinical sign is swelling, CCOCs can metastasize, and the prognosis is fair.

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Data Availability

Yes, we have all the information that was used to perform the manuscript. Data analyses were performed with Microsoft Excel 2018 (Microsoft Corp, Redmond, Washington).

Code Availability

Statistical Package for the Social Sciences (SPSS) software, version 20.0 ©Copyright IBM (SPSS Inc., Chicago, IL, USA).

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  1. av 5 de diciembre, 3303, Acarigua Portuguesa, Venezuela

    Alberto Jose Peraza Labrador

  2. Department of Otolaryngologist Military Hospital, Bogota, Colombia

    Nestor Ricardo Gonzalez Marin

  3. Las Golondrinas Mz. B lote 9. Los Olivos, Lima, Peru

    Luciano Hermios Matos Valdez

  4. Universidad de Cuenca Facultad de Odontologia, Cuenca, Ecuador

    Martinez P. Valentina

  5. Av. El Olivar 3879 San Martin de Porres, Lima, Peru

    Katman Bear Toledo Sanchez

  6. Av. Pablo Carriquiry 705 San Isidro, Lima, Peru

    Karem Annelise Rodriguez Ibazetta

  7. All Medical Group, Bogota, Colombia

    Basterrechea Johan

  8. Universidad Señor de SIPAN Dental School, Chiclayo, Peru

    Abad Villacrez Cesar

  9. Department of Diagnostic Sciences, Texas A&M University College of Dentistry, 3302, Gaston Ave, Dallas, TX, 75246, USA

    John M. Wright

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AJPL: action performed: search and paper selection, prospero writing, data analyze, oxford codification, excel data, discussion writing. NRGM: action performed: data analyzes, stadistic software analyzes, Table 1. LHMV: action performed: paper selection, oxford codification for papers, writing. MPV. action performed: excel data, Table 1, and oxford codification. KBTS: action performed: excel data, oxford codification, Fig. 2. KARI: action performed: oxford codification, Table 2, prospero writing. BJ: action performed: Fig. 1, Table 3, discussion writing. AVC: action performed: excel data for immunohistochemistry, Fig. 2, Fig. 1. JMW: regents professor, action performed: writing results, oxford codification, Table 4, data analyzes Figs. 3, 4.

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Labrador, A.J.P., Marin, N.R.G., Valdez, L.H.M. et al. Clear Cell Odontogenic Carcinoma a Systematic Review. Head and Neck Pathol 16, 838–848 (2022). https://doi.org/10.1007/s12105-021-01383-9

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