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The leading established metal-based drugs: a revisitation of their relevant physico-chemical data

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Abstract

The study of metal-based drugs represents an important branch of modern bioinorganic chemistry. The growing importance of this field is linked to the large success in medicine of a few metal based drugs, either in clinical use or still experimental. Moreover, these metal-based drugs are frequently used as reference compounds to assess comparatively the behavior of newly synthesized metallodrugs. For the convenience of researchers working in this area we report here a compilation of the relevant analytical and spectroscopic data of ten representative metallodrugs based on Platinum, Ruthenium, Gold and Mercury. The selected compounds, namely Cisplatin, Oxaliplatin, Carboplatin, Auranofin, Sodium Aurothiomalate, NAMI-A, KP1019, Thimerosal, Merbromin and Phenylmercury Acetate, were chosen owing to their importance in the field. We believe that this compilation may turn very helpful to researchers as these data are difficult to find and generally scattered over a large number of (old) publications.

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References

  • Alessio E (2017) Thirty years of the drug candidate NAMI-A and the myths in the field of ruthenium anticancer compounds: a personal perspective. Eur J Inorg Chem 12:1549–1560

    Article  CAS  Google Scholar 

  • Benedek TG (2004) The history of gold therapy for tuberculosis. J Hist Med Allied Sci 59:50–89

    Article  PubMed  Google Scholar 

  • Cirri D, Pillozzi S, Gabbiani C, Tricomi J, Bartoli G, Stefanini M, Michelucci E, Arcangeli A, Messori L, Marzo T (2017) PtI2(DACH), the iodido analogue of oxaliplatin as a candidate for colorectal cancer treatment: chemical and biological features. Dalton Trans 46:3311–3317

    Article  CAS  PubMed  Google Scholar 

  • Colebrook L, Hare R (1927) On the bactericidal action of mercurochrome. Br J Exp Pathol 8:109–114

    PubMed Central  Google Scholar 

  • Database of privately and publicly funded clinical studies conducted around the world. https://clinicaltrials.gov. Accessed 08 Apr 2011

  • Geier J, Lessmann H, Uter W, Schnuch A (2005) Patch testing with p-toluene diamine preparations of different ages. Contact Dermat 53:117–118

    Article  CAS  Google Scholar 

  • Hospital formulary and compendium of useful information (1941) Berkeley, California: University of California Press, p 113

  • Kean WF, Hart L, Buchanan WW (1997) Auranofin. Br J Rheumatol 36:560–572

    Article  CAS  PubMed  Google Scholar 

  • Marzo T, Pillozzi S, Hrabina O, Kasparkova J, Brabec V, Arcangeli A, Bartoli G, Severi M, Lunghi A, Totti F, Gabbiani C, Quiroga AG, Messori L (2015) cis-PtI2(NH3)2: a reappraisal. Dalton Trans 44:14896–14905

    Article  CAS  PubMed  Google Scholar 

  • Marzo T, Cirri D, Gabbiani C, Gamberi T, Magherini F, Pratesi A, Guerri A, Biver T, Binacchi F, Stefanini M, Arcangeli A, Messori L (2017) Auranofin, Et3PAuCl, and Et3PAuI are highly cytotoxic on colorectal cancer cells: a chemical and biological study. ACS Med Chem Lett 8:997–1001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Marzo T, Cirri D, Pollini S, Prato M, Fallani S, Cassetta MI, Novelli A, Rossolini GM, Messori L (2018) Auranofin and its analogues show potent antimicrobial activity against multidrug-resistant pathogens: structure-activity relationships. Chem Med Chem 13:2448–2454

    Article  CAS  PubMed  Google Scholar 

  • Marzo T, Massai L, Pratesi A, Stefanini M, Cirri D, Magherini F, Becatti M, Landini I, Nobili S, Mini E, Crociani O, Arcangeli A, Pillozzi S, Gamberi T, Messori L (2019) Replacement of the thiosugar of auranofin with iodide enhances the anticancer potency in a mouse model of ovarian cancer. ACS Med Chem Lett 10:656–660

    Article  CAS  PubMed  Google Scholar 

  • Muggia FM, Bonetti A, Hoeschele JD, Rozencweig M, Howell SB (2015) Platinum antitumor complexes: 50 years since barnett rosenberg’s discovery. J Clin Oncol 33:4219–4226

    Article  CAS  PubMed  Google Scholar 

  • Rorder C, Thomson MJ (2015) Auranofin: repurposing an old drug for a golden new age. Drugs R D 15(13):20

    Google Scholar 

  • Sharpe MA, Livingston AD, Baskin DS (2012) Thimerosal-derived ethylmercury is a mitochondrial toxin in human astrocytes: possible role of fenton chemistry in the oxidation and breakage of mtDNA. J Toxicol 2012:373678

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

L.M. and A.P. acknowledge the Fondazione Italiana per la Ricerca sul Cancro (AIRC), Milan, and Fondazione Cassa Risparmio Firenze for funding the project “Advanced mass spectrometry tools for cancer research: novel applications in proteomics, metabolomics and nanomedicine” (Multi-user Equipment Program 2016, Ref. code 19650). D.C. gratefully thanks Fondazione Italiana per la Ricerca sul Cancro (AIRC) for the financial support (1-year Fellowship for Italy; project code: 22294). The MetMed group acknowledge Simone Ventisette for the work done during his traineeship in determining LogP of these compounds. T.M. thanks University of Pisa (Rating Ateneo 2018 and 2019) for financial support.

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Author notes

  1. Tiziano Marzo and Luigi Messori have contributed equally to this work.

Authors and Affiliations

  1. Laboratory of Metals in Medicine (MetMed), Department of Chemistry Ugo Schiff, University of Florence, Via della Lastruccia 3-13, 50019, Sesto Fiorentino, Italy

    Damiano Cirri, Maria Giulia Fabbrini, Alessandro Pratesi, Lorenzo Ciofi, Lara Massai & Luigi Messori

  2. Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126, Pisa, Italy

    Tiziano Marzo

Authors
  1. Damiano Cirri
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  2. Maria Giulia Fabbrini
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  3. Alessandro Pratesi
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  4. Lorenzo Ciofi
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  5. Lara Massai
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  6. Tiziano Marzo
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  7. Luigi Messori
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Corresponding authors

Correspondence to Damiano Cirri or Luigi Messori.

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Cirri, D., Fabbrini, M.G., Pratesi, A. et al. The leading established metal-based drugs: a revisitation of their relevant physico-chemical data. Biometals 32, 813–817 (2019). https://doi.org/10.1007/s10534-019-00210-7

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