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Extranodal NK-T Cell Lymphoma, Nasal Type: Retrospective Analysis of Real-World Data

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Peripheral T cell lymphomas constitute nearly 15% of all cases on non-Hodgkin lymphoma. Of these, NK-T cell lymphoma nasal type is a rare and aggressive form. We present our experience of 16 patients of NK/T cell lymphoma which constituted approximately 1% of all lymphoma (N = 1590) cases treated at our center. Male to female ratio was 4.3:1. Median age of presentation was 42 years. Early Stage patients (n = 11) were treated with DeVIC regimen (n = 10) and SMILE (n = 1) chemotherapy and RT to all the patients. Advanced stage patients were treated with SMILE regimen (n = 4) and ICE and local RT (n = 1) with one treatment related mortality. The presence of B-symptoms adversely affected survival. The estimated median PFS and OS were 39 and 49 months respectively. Overall survival was not reached in Limited Stage patients (stage 1 and 2) and 8 months in patients with advanced stage (stage IV) (p = 0.001). According to the new CSWOG staging (retrospectively applied), comparing the Limited versus Extensive Stage, the earlier group has a significantly better estimated PFS (p = 0.020) and OS (p = 0.007). ENKTL is a rare malignancy with aggressive course. B-symptoms portend a poor prognosis to patients with this aggressive lymphoma. The new staging system helps estimate survival better.

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Acknowledgements

We would like to acknowledge an entire team of hemato-oncology and bone marrow transplant unit, Rajiv Gandhi Cancer Institute and Research Centre for their continuous support for retrieving records of eligible patients.

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Authors and Affiliations

  1. Department of Hemato-Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085, India

    Sneha J. Bothra, Pragya Bhandari, Narendra Agrawal, Narender Tejwani, Rayaz Ahmed, Vishvdeep Khushoo, Sumeet Mirgh & Dinesh Bhurani

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  1. Sneha J. Bothra
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  2. Pragya Bhandari
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  4. Narender Tejwani
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Correspondence to Narendra Agrawal.

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All procedures performed in study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by our Institutional Review Board (IRB).

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This is a retrospective study hence for this type of study formal consent is not required. IRB waived off the need to take consent for the study.

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Bothra, S.J., Bhandari, P., Agrawal, N. et al. Extranodal NK-T Cell Lymphoma, Nasal Type: Retrospective Analysis of Real-World Data. Indian J Hematol Blood Transfus 36, 260–266 (2020). https://doi.org/10.1007/s12288-019-01195-6

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  • DOI: https://doi.org/10.1007/s12288-019-01195-6

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