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Modulatory effect of photobiomodulation on stem cell epigenetic memory: a highlight on differentiation capacity

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Abstract

Differentiation potential of stem cells into various lineages makes these cells as promising sources to treat multiple diseases. In this regard, the use of different strategies and protocols to increase differentiation capacity is highly demanded. Low-level laser therapy, a relatively noninvasive technique, has the capacity to accelerate the healing of numerous injuries and a portion of restorative capacity could be correlated with the stem cell activation and differentiation. Several mechanisms have been diagnosed to participate in orientation of stem cells to functional mature cells. Among them, the status of DNA methylation orchestrates the maintenance of tissue-specific gene expression during the differentiation procedure. DNA methylation is a momentous event in embryogenesis and functional maturation. This review article highlighted the potency of laser irradiation (low-level intensities) in the differentiation of stem cells by modulation of methylation. The analysis of these modalities could help us to understand the underlying mechanisms participating in the therapeutic effects of photobiomodulation.

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Acknowledgments

We would thank the personnel of Stem Cell Research Center for collaboration.

Funding

This manuscript is supported by a grant from Tabriz University of Medical Sciences.

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Authors and Affiliations

  1. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Arezoo Rezaie Nezhad Zamani, Shirin Saberianpour & Reza Rahbarghazi

  2. Neuroscience Research Center, Imam Reza Medical Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mohammad Hossein Geranmayeh

  3. Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Farhad Bani

  4. Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Leila Haghighi

  5. Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Reza Rahbarghazi

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  1. Arezoo Rezaie Nezhad Zamani
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Contributions

A.R.N.Z., S.S., M.H.G., F.B., and L.H. collected the data and wrote manuscript. R. R. conducted the study.

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Correspondence to Reza Rahbarghazi.

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Zamani, A.R.N., Saberianpour, S., Geranmayeh, M.H. et al. Modulatory effect of photobiomodulation on stem cell epigenetic memory: a highlight on differentiation capacity. Lasers Med Sci 35, 299–306 (2020). https://doi.org/10.1007/s10103-019-02873-7

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  • DOI: https://doi.org/10.1007/s10103-019-02873-7

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