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Usefulness and clinical relevance of left ventricular global longitudinal systolic strain in patients with heart failure with preserved ejection fraction

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Abstract

In recent years, several studies have shown the usefulness and clinical relevance of left ventricular global longitudinal systolic strain (GLS) in different cardiovascular diseases. In line with this, the role of GLS in patients with heart failure with preserved ejection fraction (HFpEF) has achieved great importance in this predominant form of heart failure in the last years. In this regard, GLS has shown to be not only a sensitive parameter to detect subtle myocardial abnormalities but also a parameter of clinical and prognostic relevance in patients with HFpEF. In this review, we analyze the current evidence concerning the clinical relevance of GLS in patients with HFpEF and we discuss the potential usefulness of GLS in this complex and heterogeneous condition for which so far no effective therapy exists.

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Authors and Affiliations

  1. Department of Internal Medicine and Cardiology, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum Augustenburgerplatz 1, 13353, Berlin, Germany

    Carsten Tschöpe

  2. German Center for Cardiovascular Research (DZHK), Berlin, Germany

    Carsten Tschöpe

  3. Berlin Institute of Health (BIH), Berlin, Germany

    Carsten Tschöpe

  4. Berlin Center for Regenerative Therapies (BCRT), Campus Virchow Klinikum (CVK), Berlin, Germany

    Carsten Tschöpe

  5. Cardiology Division, Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy

    Michele Senni

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  1. Carsten Tschöpe
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Tschöpe, C., Senni, M. Usefulness and clinical relevance of left ventricular global longitudinal systolic strain in patients with heart failure with preserved ejection fraction. Heart Fail Rev 25, 67–73 (2020). https://doi.org/10.1007/s10741-019-09853-7

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