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The enhancing effects of Biobran/MGN-3, an arabinoxylan rice bran, on healthy old adults’ health-related quality of life: a randomized, double-blind, placebo-controlled clinical trial

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Abstract

Purpose

The world’s older population is growing rapidly and the need to find measures to combat age-associated decline of physical, mental, and cognitive functions and improve their health-related quality of life (HRQOL) is escalating. Biobran/MGN-3, an arabinoxylan rice bran, has been previously reported to improve the quality of life in cancer patients. The objective of the current study was to examine the effect of a low dose of Biobran/MGN-3 supplementation on the HRQOL in a healthy older adult population.

Methods

Sixty apparently healthy subjects, 40 males and 20 females, over 56 years old were recruited and blindly randomized into two group receiving either placebo or Biobran/MGN-3 (250 mg/day for 3 months). Participants did not take any vitamins or medications during the study and their health was closely monitored. HRQOL was assessed at the initiation and termination of the study using the previously validated Arabic version of SF-12v2 questionnaire.

Results

For all measured HRQOL domains, there was no statistically significant difference in baseline scores between the two groups. Compared to baseline values and placebo-treated subjects, Biobran/MGN-3 supplementation significantly enhanced the levels of physical and mental component summary scores as well as role-physical, bodily pain, vitality, and social functioning subdomain scores.

Conclusion

These results show that Biobran/MGN-3 is a promising psychoneuroimmune modulatory agent that could improve the HRQOL in healthy old adults.

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Abbreviations

HRQOL:

Health-related Quality of Life

PCS:

Physical Component Summary

MCS:

Mental Component Summary

PF:

Physical Functioning

RP:

Role-Physical

RE:

Role Emotion

BP:

Bodily Pain

MH:

Mental Health

VT:

Vitality

SF:

Social Functioning

WHO:

World Health Organization

QOL:

Quality of Life

GH:

General Health

PA:

Physical Activity

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Acknowledgements

The authors would like to thank Daiwa Pharmaceutical Co., Ltd., Tokyo, Japan for providing Biobran/MGN-3. We also appreciate the assistance of Dr. B. J. Winjum in preparing the manuscript.

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Authors and Affiliations

  1. Department of Community Medicine and Public Health, Zagazig University, Zagazig, Al Sharqia, Egypt

    A. F. Elsaid

  2. Department of Neurology, Faculty of Medicine, Zagazig University, Zagazig, Al Sharqia, Egypt

    R. M. Fahmi

  3. Department of Internal Medicine, Charles R. Drew University of Medicine and Science, 1621 E. 120th Street, Los Angeles, CA, 90059, USA

    M. Shaheen

  4. Department of Surgery, Charles R. Drew University of Medicine and Science, 1621 E. 120th Street, Los Angeles, CA, 90059, USA

    M. Ghoneum

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  1. A. F. Elsaid
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Correspondence to M. Ghoneum.

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Conflict of interest

Dr. Elsaid, Dr. Fahmi, and Dr. Shaheen have nothing to disclose; Dr. Ghoneum has received grants from Daiwa Pharmaceutical Co., Ltd., Japan, outside the submitted work.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Zagazig University Hospital, Faculty of Medicine, IRB approval no. 1507, June 2018) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Elsaid, A.F., Fahmi, R.M., Shaheen, M. et al. The enhancing effects of Biobran/MGN-3, an arabinoxylan rice bran, on healthy old adults’ health-related quality of life: a randomized, double-blind, placebo-controlled clinical trial. Qual Life Res 29, 357–367 (2020). https://doi.org/10.1007/s11136-019-02286-7

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