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Pomalidomide, cyclophosphamide, and dexamethasone for relapsed/refractory multiple myeloma patients in a real-life setting: a single-center retrospective study

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Abstract

Pomalidomide dexamethasone is a standard of care for relapsed multiple myeloma (MM) patients who received at least two prior lines of therapy, including both lenalidomide and proteasome inhibitors (PI). We report here a real-life single-center series of 49 consecutive patients with relapsed and refractory MM treated with the triplet pomalidomide cyclophosphamide dexamethasone (PCD) combination. The median of prior lines of therapy was 3 and all patients were previously exposed to proteasome inhibitors and lenalidomide. The overall response rate was 76%, including 27% very good partial response or better. With a median follow-up of 16 months, the median progression-free survival (PFS) was 7.3 months and the median overall survival was not reached. Regarding safety, most frequent toxicity was hematologic, including 37% grade 3–4 cytopenias. Nine patients (18%) discontinued therapy due to adverse event. Our study confirms that PCD combination is feasible and results in favorable response rate and PFS in comparison with pomalidomide dexamethasone alone.

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Acknowledgements

CT, PM, and SLG are members of Site de Recherche Intégrée sur le Cancer (SIRIC) « ILIAD » (INCA-DGOS-Inserm_12558).

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Authors and Affiliations

  1. Department of Hematology, Centre Hospitalier Universitaire, Nantes, France

    Sabrina Trudel, Benoît Tessoulin, Maxime Jullien, Nicolas Blin, Thomas Gastinne, Béatrice Mahé, Viviane Dubruille, Antoine Bonnet, Anne Lok, Patrice Chevallier, Pierre Peterlin, Alice Garnier, Thierry Guillaume, Amandine Le Bourgeois, Steven Le Gouill, Philippe Moreau & Cyrille Touzeau

  2. CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes, Nantes, France

    Benoît Tessoulin, Steven Le Gouill, Philippe Moreau & Cyrille Touzeau

  3. Site de Recherche Intégrée sur le Cancer (SIRIC) «ILIAD», Nantes, France

    Steven Le Gouill, Philippe Moreau & Cyrille Touzeau

  4. Service d’hématologie Clinique, Centre Hospitalier Universitaire, Place Alexis Ricordeau, 44093, Nantes, France

    Cyrille Touzeau

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  1. Sabrina Trudel
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  2. Benoît Tessoulin
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  3. Maxime Jullien
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  4. Nicolas Blin
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  17. Cyrille Touzeau
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Contributions

CT, PM, and ST designed the study. ST collected the data. ST and BT performed statistical analysis. CT and ST wrote the manuscript. All authors treated patients and critically reviewed the manuscript and gave the final approval.

Corresponding author

Correspondence to Cyrille Touzeau.

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Conflict of interest

CT and PM are advisory board member and received honoraria from Celgene.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Trudel, S., Tessoulin, B., Jullien, M. et al. Pomalidomide, cyclophosphamide, and dexamethasone for relapsed/refractory multiple myeloma patients in a real-life setting: a single-center retrospective study. Ann Hematol 98, 1441–1447 (2019). https://doi.org/10.1007/s00277-019-03649-3

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  • DOI: https://doi.org/10.1007/s00277-019-03649-3

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