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Transforming growth factor-β1 in children with diabetic nephropathy

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Abstract

Background

Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that has numerous biological processes. Earlier research indicates that protein and mRNA production of TGF-β1 are enhanced in the renal tissues of patients with diabetic nephropathy (DN). Our aim was to evaluate the role of TGF-β1 in early prediction of DN in children with type 1 diabetes mellitus (T1DM).

Methods

Fifty patients with T1DM were enrolled in an observational study. Patients were eligible to participate if at least 3 years had passed since T1DM diagnosis. Patients were classified into two groups (A and B) according to the presence or absence of microalbuminuria, respectively. Serum TGF-β1 was measured by ELISA in the patients.

Results

Out of the 50 studied patients with T1DM, there were 23 (46%) patients with microalbuminuria. There was a significant difference between patients in group A and B as regards TGF-β1 (p < 0.001). HbA1c had very little influence in controlling for the relationship between TGF-β1 and disease duration. Diagnostic cutoff value of TGF-β1 was 358.5 pg/ml with sensitivity and specificity of 100%.

Conclusion

TGF-β1 was significantly higher in children with DN in comparison with children without. It could be used as an early indicator of DN in children with T1DM with high sensitivity and specificity.

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Authors and Affiliations

  1. Pediatric Nephrology & Transplantation Center, Cairo University, Cairo, Egypt

    Happy Sawires

  2. Pediatric Department, Beni Suef University, Beni Suef, Egypt

    Osama Botrous & Abdelmegeed Aboulmagd

  3. Microbiology Department, Cairo University, Giza, Egypt

    Nadia Madani

  4. Pediatric Department, Beni Suef General Hospital, Ministry of Health, Beni Suef, Egypt

    Osama Abdelhaleem

Authors
  1. Happy Sawires
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  2. Osama Botrous
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  3. Abdelmegeed Aboulmagd
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  4. Nadia Madani
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  5. Osama Abdelhaleem
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Corresponding author

Correspondence to Happy Sawires.

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The study was conducted in accordance with the Declaration of Helsinki and approved by the local ethics committee.

Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights and informed consent

An informed consent was obtained from patients’ caregivers. The research does not include animals and there were no clinical trials on human subjects.

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Sawires, H., Botrous, O., Aboulmagd, A. et al. Transforming growth factor-β1 in children with diabetic nephropathy. Pediatr Nephrol 34, 81–85 (2019). https://doi.org/10.1007/s00467-018-4062-8

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  • DOI: https://doi.org/10.1007/s00467-018-4062-8

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