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Pluronic-Based Mixed Polymeric Micelles Enhance the Therapeutic Potential of Curcumin

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Abstract

Curcumin is a naturally occurring constituent of turmeric that is a good substitute for synthetic medicines for the treatment of different diseases, due to its comparatively safer profile. However, there are certain shortcomings that limit its use as an ideal therapeutic agent. In order to overcome these drawbacks, we prepared novel curcumin-loaded mixed polymeric micelles using different biocompatible polymers by the thin-film hydration method. We investigated the critical micelle concentration and temperature, drug loading and encapsulation efficiency, and minimum inhibitory concentration by spectrophotometry. Surface morphology, stability, particle size, drug-polymer interaction, and physical state of the prepared formulations were investigated using scanning electron microscopy, zeta potential, particle size analyzer, Fourier-transform infrared spectroscopy, and X-ray diffraction, respectively. The drug loading and entrapment efficiency were significantly increased (P < 0.01) when curcumin was encapsulated with pluronic-based mixed polymeric micelles as compared to that of pluronic-based micelles alone. In vitro studies exhibited that pluronic-based mixed polymeric micelles significantly increased anticancer (P < 0.01), antimicrobial (P < 0.001), antioxidant (P < 0.001), and α-amylase inhibitory (P < 0.001) activities when compared to pure curcumin and/or pluronic-based micelles alone. These findings suggest that the formation of mixed polymeric micelles increases the stability and solubility of curcumin.

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Authors and Affiliations

  1. Department of Applied Chemistry, Government College University, Faisalabad, Pakistan

    Muhammad Usman Akbar & Khalid Mahmood Zia

  2. Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan

    Muhammad Usman Akbar & Muhammad Sajid Hamid Akash

  3. Department of Textile Chemistry, National Textile University, Faisalabad, Pakistan

    Ahsan Nazir

  4. Center for Advanced Drug Research, Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan

    Jamshed Iqbal & Syeda Abida Ejaz

Authors
  1. Muhammad Usman Akbar
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  2. Khalid Mahmood Zia
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  3. Ahsan Nazir
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  4. Jamshed Iqbal
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  5. Syeda Abida Ejaz
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  6. Muhammad Sajid Hamid Akash
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Correspondence to Khalid Mahmood Zia or Muhammad Sajid Hamid Akash.

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Akbar, M.U., Zia, K.M., Nazir, A. et al. Pluronic-Based Mixed Polymeric Micelles Enhance the Therapeutic Potential of Curcumin. AAPS PharmSciTech 19, 2719–2739 (2018). https://doi.org/10.1208/s12249-018-1098-9

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