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Multiplexing technology for in vitro diagnosis of pathogens: the key contribution of phosphorus dendrimers

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Abstract

After the microbiology based on Pasteur’s method and polymerase chain reaction (PCR), the diagnosis company named Dendris has proposed a third-generation of diagnosis enabling the search of a broad range of pathogens with strong sensitivity and specificity. This extraordinary profile was possible thanks to the use of phosphorus dendrimers for which various techniques of deposition on a given support were investigated and described and analyzed in this report.

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Acknowledgements

This work was supported by the National Research Agency (Agence Nationale pour la Recherche), “BIOTECHNOLOGIES” program (ANR 2010 BIOT 004 06: Project INNODIAG to JMF) and by Region Midi Pyrénées (06001324 & 07006292) to RF and JMF and by CNRS (JPM, AMC).

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Authors and Affiliations

  1. Laboratoire de Chimie de Coordination du CNRS, 31077, Toulouse Cedex 4, France

    Jean Pierre Majoral & Anne-Marie Caminade

  2. LCC-CNRS Université de Toulouse, CNRS, Toulouse, France

    Jean Pierre Majoral & Anne-Marie Caminade

  3. Dendris, 31670, Labège, France

    Jean Pierre Majoral, Jean Marie François, Richard Fabre & Alice Senescau

  4. LISBP, UMR CNRS 5504 INRA 792, 31077, Toulouse Cedex 04, France

    Jean Marie François

  5. Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicolgique, Université Paris Descartes PRES Sorbonne Paris Cité, CNRS-UMR 860, 75006, Paris, France

    Serge Mignani

Authors
  1. Jean Pierre Majoral
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  2. Jean Marie François
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  3. Richard Fabre
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  4. Alice Senescau
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  5. Serge Mignani
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  6. Anne-Marie Caminade
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Corresponding author

Correspondence to Jean Pierre Majoral.

Additional information

Jean-Pierre Majoral is Emeritus Director of Research, Exceptional Class at the CNRS in Toulouse. His research interest is focused on the design and the properties of macromolecules such as phosphorus dendrimers and hyperbranched polymers. Main efforts are directed at the use of dendrimers in medicinal chemistry, material sciences and catalysis. He is cofounder and scientific director of the start-up Dendris. He is a member of several Academies of Sciences worldwide, got a dozen of international awards, and is an author of over 635 publications, 7 books, 35 book chapters, and 45 patents (h index 65, over 15,700 citations).

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Majoral, J.P., François, J.M., Fabre, R. et al. Multiplexing technology for in vitro diagnosis of pathogens: the key contribution of phosphorus dendrimers. Sci. China Mater. 61, 1454–1461 (2018). https://doi.org/10.1007/s40843-018-9253-5

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  • DOI: https://doi.org/10.1007/s40843-018-9253-5

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